The monitoring of hematopoietic stem cell transplant donors and recipients from endemic areas for malaria

Authors

  • Juliana Inoue Health Secretariat of Sao Paulo State; Superintendence of Endemic Diseases Control; Malaria Research Center
  • Clarisse Martins Machado Amaral Carvalho Foundation; Hematopoietic Stem Cell Transplant Program
  • Giselle Fernandes Maciel de Castro Lima Health Secretariat of Sao Paulo State; Superintendence of Endemic Diseases Control; Malaria Research Center
  • Maria de Jesus Costa Nascimento Health Secretariat of Sao Paulo State; Superintendence of Endemic Diseases Control; Malaria Research Center
  • Vergílio Rensi Colturato Amaral Carvalho Foundation; Hematopoietic Stem Cell Transplant Program
  • Silvia Maria Di Santi Health Secretariat of Sao Paulo State; Superintendence of Endemic Diseases Control; Malaria Research Center

Keywords:

Hematopoietic stem cell transplantation, Malaria, Molecular diagnostic, Microscopy

Abstract

Malaria is an unusual complication after hematopoietic stem cell transplantation in non-endemic countries. However, transplant candidates, recipients and donors living in endemic regions frequently report previous episodes of malaria. This fact could represent an important risk for immunosuppressed recipients that could develop severe malaria cases. We report a case of hematopoietic stem cell transplant (HSCT) in which the donor had a history of previous malaria, and close monitoring was performed before and after procedure by parasitological and molecular tests. The donor presented Plasmodium vivax in thick blood smears one month after transplant and was treated according to Brazilian Health Ministry guidelines. The polymerase chain reaction (PCR) was able to detect malaria infection in the donor one week earlier than thick blood film. Even without positive results, the recipient was pre-emptively treated with chloroquine in order to prevent the disease. We highlight the importance of monitoring recipients and donors in transplant procedures with the aim of reducing the risk of malaria transmission.

Downloads

Download data is not yet available.

Downloads

Published

2010-10-01

Issue

Section

Case Reports

How to Cite

Inoue, J., Machado, C. M., Lima, G. F. M. de C., Nascimento, M. de J. C., Colturato, V. R., & Di Santi, S. M. (2010). The monitoring of hematopoietic stem cell transplant donors and recipients from endemic areas for malaria . Revista Do Instituto De Medicina Tropical De São Paulo, 52(5), 281-284. https://revistas.usp.br/rimtsp/article/view/31353