CMV and HSV-2 myeloradiculitis in an HIV infected patient

Authors

  • Adriana Pinto FIOCRUZ; Instituto de Pesquisa Clínica Evandro Chagas
  • Edwiges Santos FIOCRUZ; Instituto de Pesquisa Clínica Evandro Chagas
  • Danusa F. Correa FIOCRUZ; Instituto de Pesquisa Clínica Evandro Chagas
  • Rodrigo Escada FIOCRUZ; Instituto de Pesquisa Clínica Evandro Chagas
  • Carla de Mello Vorsatz FIOCRUZ; Instituto de Pesquisa Clínica Evandro Chagas
  • Sandra Wagner Cardoso FIOCRUZ; Instituto de Pesquisa Clínica Evandro Chagas
  • Marco A. Lima FIOCRUZ; Instituto de Pesquisa Clínica Evandro Chagas

Keywords:

Cytomegalovirus, Herpes simplex 2, HIV, Myelitis, Foscarnet, Ganciclovir

Abstract

While CMV myeloradiculitis is a known complication in AIDS patients with severe immunosuppression, HSV-2 necrotizing myeloradiculitis is rare and often associated with disabling a fatal outcome. We hereby describe a 46 year-old HIV infected patient with profound and sustained immunosuppression who presented with an acute ascending paraparesis and urinary retention. Lumbar spine MRI showed contrast enhancement at the conus medullaris and cauda equine, and both CMV and HSV-2 CSF PCR were positive. Despite treatment, the patient died 20 days later. We review the main diagnostic and therapeutic aspects of herpes virus associated myeloradiculitis and discuss the approach in similar cases.

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Published

2011-06-01

Issue

Vol. 53 No. 3 (2011)

Section

Case Reports

How to Cite

Pinto, A., Santos, E., Correa, D. F., Escada, R., Vorsatz, C. de M., Cardoso, S. W., & Lima, M. A. (2011). CMV and HSV-2 myeloradiculitis in an HIV infected patient . Revista Do Instituto De Medicina Tropical De São Paulo, 53(3), 173-175. https://revistas.usp.br/rimtsp/article/view/31398