HISTOPLASMIN SURVEY IN HIV-POSITIVE PATIENTS: RESULTS FROM AN ENDEMIC AREA IN NORTHEASTERN BRAZIL

Authors

  • Fabricia Salvador Bezerra Federal University of Ceara; School of Medicine; Department of Community Health
  • Rosely Maria Zancope-Oliveira Fundacao Oswaldo Cruz, Fiocruz; Mycology Department. Instituto de Pesquisa Evandro Chagas
  • Raimunda Samia Nogueira Brilhante Federal University of Ceara; Medical Mycology Research Center
  • Bodo Wanke Fundacao Oswaldo Cruz, Fiocruz; Mycology Department. Instituto de Pesquisa Evandro Chagas
  • Rosa Maria Salani Mota Federal University of Ceara; School of Medicine; Department of Community Health
  • Ana Paula Gomes Ramos Municipal Health Department. Fortaleza; Center of Medical Specialties Jose de Alencar
  • Alberto Novaes Ramos Jr. Federal University of Ceara; School of Medicine; Department of Community Health
  • Monica Cardoso Facanha Federal University of Ceara; School of Medicine; Department of Community Health
  • Terezinha do Menino Jesus Silva Leitao Federal University of Ceara; School of Medicine; Department of Community Health

Abstract

SUMMARY Background. Disseminated histoplasmosis is common in AIDS patients with advanced immunosuppression in Ceará, Northeastern Brazil. The goal of this study was to determine the prevalence of Histoplasma infection in patients with HIV/AIDS living in Fortaleza, the capital of Ceará. Methods. Intradermal tests with histoplasmin (mycelial phase) were performed in 161 HIV patients with CD4 ≥ 350 cells/mm 3 . Evidence of recent illness was evaluated with immunodiffusion (ID) tests in 76 of these individuals. Results. A total of 11.8% of patients reacted to histoplasmin and 2.63% had ID test positive to Histoplasma. The presence of mango trees (Mangifera indica) in the patient neighborhood (OR = 2.870; 95% CI = 1.081-7.617; p = 0.040) and past activity involving soil (OR = 2.834; 95% CI = 1.045-7.687; p = 0.045) or visits to a farm (OR = 3.869; 95% CI = 1.189-12.591; p = 0.033) were significantly associated with Histoplasma infection. Conclusions. Patients with HIV living in Fortaleza have an expressive prevalence of infection with Histoplasma.

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Published

2013-07-01

Issue

Vol. 55 No. 4 (2013)

Section

HIV/AIDS

How to Cite

Bezerra, F. S., Zancope-Oliveira, R. M., Brilhante, R. S. N., Wanke, B., Mota, R. M. S., Ramos, A. P. G., Ramos Jr., A. N., Facanha, M. C., & Leitao, T. do M. J. S. (2013). HISTOPLASMIN SURVEY IN HIV-POSITIVE PATIENTS: RESULTS FROM AN ENDEMIC AREA IN NORTHEASTERN BRAZIL . Revista Do Instituto De Medicina Tropical De São Paulo, 55(4), 261-265. https://revistas.usp.br/rimtsp/article/view/78653