Association of Amphotericin B and Rifampicin in the treatment of paracoccidioidomycosis. Report of efficacy in three cases

Authors

  • Bodo Wanke Instituto Oswaldo Cruz; Departamento de Micologia
  • Paulo Nolasco Pedrosa U.F.R.J; Dep. de Medicina Preventiva
  • Gustavo Dos Santos Brêtas Uni-Rio
  • Sérgio Setúbal U.F.R.J; Dep. de Medicina Preventiva

Abstract

Experimental data have shown that low concentration of amphotericin B disrupts of the fungal cellular membranes, enhancing entrance of rifampicin into citoplasm, where it acts specifically as an antifungal agent against Histoplasma capsulatum, Blastomyces dermatitidis and Candida albicans. Amphotericin B in half dosage combined with rifampicin is more effective than when used alone in full dosage. The Authors discuss the possible indications of this association in the therapy of paracoccidioidomycosis, and report its efficacy in three cases of this disease only controlled after its use.

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Published

1984-08-01

Issue

Section

Therapeutic Assays

How to Cite

Wanke, B., Pedrosa, P. N., Brêtas, G. D. S., & Setúbal, S. (1984). Association of Amphotericin B and Rifampicin in the treatment of paracoccidioidomycosis. Report of efficacy in three cases . Revista Do Instituto De Medicina Tropical De São Paulo, 26(4), 205-211. https://revistas.usp.br/rimtsp/article/view/87303