Neurotoxicity of oxamniquine in the treatment of human infection due to S. mansoni

Authors

  • Silvino Alves de Carvalho Universidade de São Paulo; Faculdade de Medicina; Clínica de Doenças Infecciosas e Parasitárias
  • Maria Aparecida Shikanai-Yasuda Universidade de São Paulo; Faculdade de Medicina; Clínica de Doenças Infecciosas e Parasitárias
  • Vicente Amato Neto Universidade de São Paulo; Faculdade de Medicina; Clínica de Doenças Infecciosas e Parasitárias
  • Mario Shiroma Universidade de São Paulo; Faculdade de Medicina; Clínica de Doenças Infecciosas e Parasitárias
  • Francisco José Carchedi Luccas Universidade de São Paulo; Faculdade de Medicina; Hospital das Clínicas; Serviço de Eletroencefalografia da Clínica Neurológica

Abstract

One hundred and eighty patients from the "Clínica de Doenças Infecciosas e Parasitárias do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo" with mansonic schistosomiasis have been treated with oxamniquine (single oral dose 12.5 15 mg or 16-20 mg/kg body weight, respectively to patients younger or older than 15 years old). The patients were 5 to 65 years old and the predominant clinical forms were intestinal and hepato-intestinal disease. The main neuropsychiatric side effects were: drowsiness (50.6%), dizziness (41.1%), headache (16.1%), temporary amnesia (2.2%), behaviour disturbances (1.7%), chills (1.1%), seizures (1.1%). In 20 patients the neurotoxicity associated with the drug has been evaluated comparing the electroencephalogram before and after the treatment. Alterations have been detected in 3 (15%) but were not associated with neuropsychiatric manifes- tations. The results show that oxamniquine determines toxic side effects in the neuropsychiatric area.

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Published

1985-06-01

Issue

Section

Original Articles

How to Cite

Carvalho, S. A. de, Shikanai-Yasuda, M. A., Amato Neto, V., Shiroma, M., & Luccas, F. J. C. (1985). Neurotoxicity of oxamniquine in the treatment of human infection due to S. mansoni . Revista Do Instituto De Medicina Tropical De São Paulo, 27(3), 132-142. https://revistas.usp.br/rimtsp/article/view/87371