Characterization of P. falciparum strains obtained from recrudescent patients

Authors

  • Virgilio E. do Rosário FSESP; Instituto Evandro Chagas; Unidade de Estudos da Malária
  • Álvaro A. Couto FSESP; Instituto Evandro Chagas; Unidade de Estudos da Malária
  • Marco A. Santos FSESP; Instituto Evandro Chagas; Unidade de Estudos da Malária
  • José Maria de Souza Hospital Barros Barreto — Projeto Mefloquina; Centro de Provas Clínico-Farmacológicas

Abstract

Characterization of Plasmodium falciparum strains obtained from three patients interned in the Clinico-Pharmalogical Testing Centre of the Barros Barreto Hospital, Belém, Pará, Brazil, was carried out using cellulose acetate electrophoresis for the two enzymes glucose phosphate isomerase EC.5.3.1.9 (GPI) and adenosine diaminase EC.3.5.4.4 (ADA) and sensibility tests for the two antimalarial drugs, chloroquin and mefloquine. This characterization showed an enzyme variant in one of the patients, and a modification in the chloroquine sensibility level in another; not only in the strains from the original infections, but also in those from each of the relapses.

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Published

1985-10-01

Issue

Vol. 27 No. 5 (1985)

Section

Case Reports

How to Cite

Rosário, V. E. do, Couto, Álvaro A., Santos, M. A., & Souza, J. M. de. (1985). Characterization of P. falciparum strains obtained from recrudescent patients . Revista Do Instituto De Medicina Tropical De São Paulo, 27(5), 274-278. https://revistas.usp.br/rimtsp/article/view/87420