Histopathology of mucocutaneous leishmaniasis caused by Leishmania braziliensis braziliensis: 1. Histological patterns and evolutive study of the lesions

Authors

  • Albino Verbosa de Magalhães Universidade de Brasília; Departamento de Medicina Complementar; Laboratório de Patologia
  • Mario A. P. Moraes Universidade de Brasília; Departamento de Medicina Complementar; Laboratório de Patologia
  • Alberto N. Raick Universidade de Brasília; Departamento de Medicina Complementar; Laboratório de Patologia
  • Alejandro Llanos-Cuentas Universidade de Brasília
  • Jackson M. L. Costa Universidade de Brasília
  • Cesar C. Cuba Universidade de Brasília
  • Philip D. Marsden Universidade de Brasília

Abstract

The Authors describe the histopathological findings observed in biopsies from 378 cases of Mucocutaneous Leishmaniasis, caused by Leishmania braziliensis braziliensis. All the patients lived in the locality of Três Braços, State of Bahia, an endemic area of Leishmaniasis in Brazil. Parasites were found in 63.7% of patients with cutaneous form and in 35.7% of cases with mucous lesions, although always in reduced number. Histopathologic findings allowed the caracterization of five different patterns: 1. Exsudative-cellular reaction, due to infiltraction of histiocytes, lymphocytes and plasm cells; 2. Exsudative-necrotic reaction, characterized by the association of necrosis with cellular infiltration; 3. Exsudative and necrotic-granulomatous reaction, corresponding to pattern described as chronic-granulomatous inflammation with necrosis; 4. Exsudativegranulomatous reaction, characterized a disorganized granulomatous reaction, without tissue necrosis; 5. Exsudative-tuberculoid reaction in which a typical tuberculoid granuloma is formed. The follow-up study in 49 patients showed, in sucessive biopsies, changes in the histopathologic patterns in 63.2% of cutaneous forms and in 45.4% of the mucous forms. It was concluded that the exsudative-cellular reaction represents both the inicial and final pattern of Mucocutaneous Leishmaniasis lesion. The other four histopathologic patterns characterize intermediate forms found during the evolution of the disease.

Downloads

Download data is not yet available.

Published

1986-08-01

Issue

Section

Original Articles

How to Cite

Magalhães, A. V. de, Moraes, M. A. P., Raick, A. N., Llanos-Cuentas, A., Costa, J. M. L., Cuba, C. C., & Marsden, P. D. (1986). Histopathology of mucocutaneous leishmaniasis caused by Leishmania braziliensis braziliensis: 1. Histological patterns and evolutive study of the lesions . Revista Do Instituto De Medicina Tropical De São Paulo, 28(4), 253-262. https://revistas.usp.br/rimtsp/article/view/87497