Schistosoma mansoni: effects of anesthetics and antimonial drugs on worm shift in the mouse

Authors

  • José Renan da Cunha-Melo Universidade Federal de Minas Gerais; Faculdade de Medicina; Departamento de Cirurgia
  • Paulo Marcos Z. Coelho Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Parasitologia

Abstract

Mice experimentally infected with Schistosoma mansoni were injected with sodium thiopental or sodium antimonyl gluconate (Triostib R), or submitted to halothane inhalation, with or without a previous injection of thiopental. Data obtained showed that halothane and thiopental induce worm shift to the liver (99 and 76%, respectively). Sodium gluconate and antimonium (Triostib R) shifted 52% of worms towards the liver. These results seem to indicate that the use of antimonium would be unnecessary, when surgical removal of schistosomules is carried out through the extracorporeal filtration technique, in patients with portal hypertension.

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Published

1986-08-01

Issue

Section

Therapeutic Assays

How to Cite

Cunha-Melo, J. R. da, & Coelho, P. M. Z. (1986). Schistosoma mansoni: effects of anesthetics and antimonial drugs on worm shift in the mouse . Revista Do Instituto De Medicina Tropical De São Paulo, 28(4), 267-270. https://revistas.usp.br/rimtsp/article/view/87499