Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni

Abstract

In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful. The parental generation treated with the drug during the immature stage of the worm was less susceptible to the chemotherapeutic agents than generations F1 and F2. A hypothesis is suggested as an explanation.