Survival and mortality among users and non-users of hydroxyurea with sickle cell disease

Authors

  • Olinda Maria Rodrigues de Araujo Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato Grosso do Sul
  • Maria Lúcia Ivo Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato Grosso do Sul
  • Marcos Antonio Ferreira Júnior Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio Grande do Norte
  • Elenir Rose Jardim Cury Pontes Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato Grosso do Sul
  • Ieda Maria Gonçalves Pacce Bispo Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato Grosso do Sul
  • Eveny Cristine Luna de Oliveira Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato Grosso do Sul

DOI:

https://doi.org/10.1590/0104-1169.3385.2526

Abstract

OBJECTIVE: to estimate survival, mortality and cause of death among users or not of hydroxyurea with sickle cell disease. METHOD: cohort study with retrospective data collection, from 1980 to 2010 of patients receiving inpatient treatment in two Brazilian public hospitals. The survival probability was determined using the Kaplan-Meier estimator, survival calculations (SPSS version 10.0), comparison between survival curves, using the log rank method. The level of significance was p=0.05. RESULTS: of 63 patients, 87% had sickle cell anemia, with 39 using hydroxyurea, with a mean time of use of the drug of 20.0±10.0 years and a mean dose of 17.37±5.4 to 20.94±7.2 mg/kg/day, raising the fetal hemoglobin. In the comparison between those using hydroxyurea and those not, the survival curve was greater among the users (p=0.014). A total of 10 deaths occurred, with a mean age of 28.1 years old, and with Acute Respiratory Failure as the main cause. CONCLUSION: the survival curve is greater among the users of hydroxyurea. The results indicate the importance of the nurse incorporating therapeutic advances of hydroxyurea in her care actions.

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Published

2015-02-01

Issue

Vol. 23 No. 1 (2015)

Section

Original Articles

License

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Including names of authors whose contribution does not fit into the above criteria cannot be justified. Those names can be included in the Acknowledgements section.
 Authors are fully responsible for the concepts disseminated in their manuscripts, which do not necessarily reflect the editors’ and editorial board’s opinion.

 

How to Cite

Survival and mortality among users and non-users of hydroxyurea with sickle cell disease . (2015). Revista Latino-Americana De Enfermagem, 23(1), 67-73. https://doi.org/10.1590/0104-1169.3385.2526