Aluminum as a risk factor for Alzheimer's disease

Authors

  • Pricilla Costa Ferreira University of São Paulo; Ribeirão Preto College of Nursing
  • Kamila de Almeida Piai University of São Paulo; Ribeirão Preto College of Nursing
  • Angela Maria Magosso Takayanagui University of São Paulo; Ribeirão Preto College of Nursing
  • Susana Inés Segura-Muñoz University of São Paulo; Ribeirão Preto College of Nursing

DOI:

https://doi.org/10.1590/S0104-11692008000100023

Keywords:

Alzheimer disease, aluminum, risk factors

Abstract

The purpose of the study was to condense existing scientific evidence about the relation between aluminum (Al) exposure and risk for the development of Alzheimer's Disease (AD), evaluating its long-term effects on the population's health. A systematic literature review was carried out in two databases, MEDLINE and LILACS, between 1990 and 2005, using the uniterms: "Aluminum exposure and Alzheimer Disease" and "Aluminum and risk for Alzheimer Disease". After application of the Relevance Test, 34 studies were selected, among which 68% established a relation between Al and AD, 23.5% were inconclusive and 8.5% did not establish a relation between Al and AD. Results showed that Al is associated to several neurophysiologic processes that are responsible for the characteristic degeneration of AD. In spite of existing polemics all over the world about the role of Al as a risk factor for AD, in recent years, scientific evidence has demonstrated that Al is associated with the development of AD.

Downloads

Download data is not yet available.

Downloads

Published

2008-02-01

Issue

Vol. 16 No. 1 (2008)

Section

Review Article

License

RLAE’s authorship concept is based on the substantial contribution by each of the individuals listed as authors, mainly in terms of conceiving and planning the research project, collecting or analyzing and interpreting data, writing and critical review. Indication of authors’ names under the article title is limited to six. If more, authors are listed on the online submission form under Acknowledgements. The possibility of including more than six authors will only be examined on multicenter studies, considering the explanations presented by the authors.
Including names of authors whose contribution does not fit into the above criteria cannot be justified. Those names can be included in the Acknowledgements section.
 Authors are fully responsible for the concepts disseminated in their manuscripts, which do not necessarily reflect the editors’ and editorial board’s opinion.

 

How to Cite

Aluminum as a risk factor for Alzheimer’s disease. (2008). Revista Latino-Americana De Enfermagem, 16(1), 151-157. https://doi.org/10.1590/S0104-11692008000100023