Prevalence of systemic complications of COVID-19 in critically ill patients: systematic review with meta-analysis

Authors

  • Namie Okino Sawada Universidade Federal de Alfenas, Alfenas, MG, Brasil. Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, Centro Colaborador da OPAS/OMS para o Desenvolvimento da Pesquisa em Enfermagem, Ribeirão Preto, SP, Brasil. https://orcid.org/0000-0002-1874-3481
  • Tiago Marques dos Reis Universidade Federal de Alfenas, Alfenas, MG, Brasil. https://orcid.org/0000-0002-0789-0187
  • Patrícia Scotini Freitas Universidade Federal de Alfenas, Alfenas, MG, Brasil. https://orcid.org/0000-0002-8270-8955
  • Camila Mendonça de Moraes Universidade Federal de Alfenas, Alfenas, MG, Brasil. Universidade Federal do Rio de Janeiro, Escola de Enfermagem, Macaé, RJ, Brasil. https://orcid.org/0000-0001-5544-8409
  • Bianca de Moura Peloso-Carvalho Universidade Federal de Alfenas, Alfenas, MG, Brasil. Bolsista da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brasil. https://orcid.org/0000-0001-5336-2249
  • Munyra Rocha Silva Assunção Universidade Federal de Alfenas, Alfenas, MG, Brasil. Bolsista do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brasil. Universidade José do Rosário Velano, Faculdade de Medicina, Alfenas, MG, Brasil. https://orcid.org/0000-0002-0998-3125
  • Camila Maria Silva Paraizo Horvath Universidade Federal de Alfenas, Alfenas, MG, Brasil. Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, Centro Colaborador da OPAS/OMS para o Desenvolvimento da Pesquisa em Enfermagem, Ribeirão Preto, SP, Brasil. https://orcid.org/0000-0002-3574-7361
  • Ranile Santos Silva Universidade Federal de Alfenas, Alfenas, MG, Brasil. https://orcid.org/0000-0002-5844-4224
  • Karina Dal Sasso Mendes Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, Centro Colaborador da OPAS/OMS para o Desenvolvimento da Pesquisa em Enfermagem, Ribeirão Preto, SP, Brasil. https://orcid.org/0000-0003-3349-2075

DOI:

https://doi.org/10.1590/1518-8345.7568.4609

Keywords:

COVID-19; SARS-CoV-2; Comorbidity; Critical Illness; Critical Care; Systematic Review

Abstract

Objective: to identify the prevalence of systemic complications of COVID-19 in critically ill patients, to estimate the clinical conditions that may have a worse prognosis when associated with COVID-19. Method: systematic review with meta-analysis of observational studies, based on the recommendations of the JBI Manual for Evidence Synthesis for systematic reviews of prevalence and incidence, in six databases and grey literature, period 2020 to 2024, languages Portuguese, English and Spanish. We identified 2393 publications. The selection, data extraction and methodological evaluation of the studies were carried out by two independent researchers. The meta-analysis was performed using the Freeman Tukey transformational random-effects statistical method. Results: ten papers were included. The meta-analysis of seven papers dealing with respiratory complications due to COVID-19 demonstrated a mean prevalence of 42%, (95% CI 0.2-0.66) with heterogeneity I2=97.4; the meta-analysis of 4 papers involving the prevalence of neurological complications due to COVID-19 showed an average prevalence of 62%, (95% CI 0.49- 0.74) with heterogeneity I2=87.4 and the meta-analysis of 8 studies showed a prevalence of mortality due to COVID-19 of 33%, (95% CI 0.23- 0.44) with heterogeneity I2=93.6. Conclusion: respiratory and neurological complications were the most prevalent in the reviewed studies. PROSPERO Registration: CRD42020214617.

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Published

2025-07-11

Issue

Vol. 33 (2025)

Section

Review Articles

License

Copyright (c) 2025 Revista Latino-Americana de Enfermagem

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This work is licensed under a Creative Commons Attribution 4.0 International License.

RLAE’s authorship concept is based on the substantial contribution by each of the individuals listed as authors, mainly in terms of conceiving and planning the research project, collecting or analyzing and interpreting data, writing and critical review. Indication of authors’ names under the article title is limited to six. If more, authors are listed on the online submission form under Acknowledgements. The possibility of including more than six authors will only be examined on multicenter studies, considering the explanations presented by the authors.
Including names of authors whose contribution does not fit into the above criteria cannot be justified. Those names can be included in the Acknowledgements section.
 Authors are fully responsible for the concepts disseminated in their manuscripts, which do not necessarily reflect the editors’ and editorial board’s opinion.

 

How to Cite

Sawada, N. O., Reis, T. M. dos, Freitas, P. S., Moraes, C. M. de, Peloso-Carvalho, B. de M., Assunção, M. R. S., Horvath, C. M. S. P., Silva, R. S., & Mendes, K. D. S. (2025). Prevalence of systemic complications of COVID-19 in critically ill patients: systematic review with meta-analysis. Revista Latino-Americana De Enfermagem, 33, e4609. https://doi.org/10.1590/1518-8345.7568.4609