Evaluation of the extract of Zeyheria tuberculosa with a view to products for wound healing

Authors

  • Patricia de Albuquerque Sarmento Universidade Federal de Alagoas; Escola de Enfermagem e Farmacia
  • Terezinha da Rocha Ataide Universidade Federal de Alagoas; Faculdade de Nutricao
  • Ana Paula de Souza e Pinto Universidade Federal de Alagoas; Faculdade de Medicina
  • Joao Xavier de Araujo-Junior Universidade Federal de Alagoas; Escola de Enfermagem e Farmacia
  • Ingrid Martins Leite Lucio Universidade Federal de Alagoas; Escola de Enfermagem e Farmacia
  • Maria Lysete de Assis Bastos Universidade Federal de Alagoas; Escola de Enfermagem e Farmacia

DOI:

https://doi.org/10.1590/0104-1169.3143.2385

Abstract

OBJECTIVES: to evaluate the antimicrobial, cytotoxic and healing activities of the ethanolic extract of the stems of Z. tuberculosa via topical use and/or oral ingestion. METHOD: antimicrobial assays in vitro using the disk diffusion method, the Artemia salina toxicity test, and in vivo assays with Wistar rats. From these was collected clinical, histological and biochemical data for evaluating the healing process. RESULTS: in vitro antimicrobial testing showed activity in relation to Streptococcus pyogenes, Staphylococcus aureus and Staphylococcus epidermidis, with zones of inhibition of 18, 14 and 10 mm, respectively. The best minimum inhibitory concentration was 62.5 µg/ml for S. aureus, this bacteria being chosen for the in vitro assays. Animals treated with the ointments with the extract of Z. tuberculosa showed the best results in the reduction of the wound diameter, data confirmed by the presence of re-epithelialization in the histological samples. CONCLUSION: the extract was shown to be promising for the continuation of studies which may identify the active ingredients responsible for the pharmacological activity and its mechanism of action in the process of wound healing, so as to develop a product which may be used as an alternate means in the repair of infected cutaneous wounds.

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Published

2014-01-01

Issue

Vol. 22 No. 1 (2014)

Section

Original Articles

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How to Cite

Evaluation of the extract of Zeyheria tuberculosa with a view to products for wound healing . (2014). Revista Latino-Americana De Enfermagem, 22(1), 165-172. https://doi.org/10.1590/0104-1169.3143.2385