Hydrogen-Ion Potential of Antibiotics According to the Environment Factors Temperature and Luminosity

Authors

  • Renata Maria Coelho Crepaldi Universidade Federal de São Paulo; Departamento de Enfermagem
  • Cíntia Monteiro Universidade Federal de São Paulo; Departamento de Enfermagem
  • Maria Angélica Sorgini Peterlini Universidade Federal de São Paulo; Departamento de Enfermagem
  • Mavilde da Luz Gonçalves Pedreira Universidade Federal de São Paulo; Departamento de Enfermagem

DOI:

https://doi.org/10.1590/S0104-11692010000200020

Keywords:

Pediatric Nursing, Infusions Intravenous, Hydrogen-Ion Concentration, Drug Stability, Safety

Abstract

The objective of this experimental study was to measure the pH of antibiotics administered by intravenous infusion - ceftriaxone sodium, vancomycin hydrochloride, metrodinazole, penicillin G potassium and amikacin sulfate - after reconstitution with sterile water and dilution with NaCl 0.9% or dextrose 5% in water, according to temperature and luminosity of the environment. The results showed that variation in the drugs' pH was less than 1.0 value and that some antibiotics remained acidic after dilution and maintained this chemical profile in all situations studied, suggesting that the studied environmental factors did not change the solutions' acid base characteristic. Some pH values measured characterize risk for the development of chemical phlebitis and infiltration, and it is important for clinical practice to emphasize the profile of intravenous solutions of antibiotics, considering method of dilution, and time to infusion.

Downloads

Download data is not yet available.

Downloads

Published

2010-04-01

Issue

Vol. 18 No. 2 (2010)

Section

Original Articles

License

RLAE’s authorship concept is based on the substantial contribution by each of the individuals listed as authors, mainly in terms of conceiving and planning the research project, collecting or analyzing and interpreting data, writing and critical review. Indication of authors’ names under the article title is limited to six. If more, authors are listed on the online submission form under Acknowledgements. The possibility of including more than six authors will only be examined on multicenter studies, considering the explanations presented by the authors.
Including names of authors whose contribution does not fit into the above criteria cannot be justified. Those names can be included in the Acknowledgements section.
 Authors are fully responsible for the concepts disseminated in their manuscripts, which do not necessarily reflect the editors’ and editorial board’s opinion.

 

How to Cite

Crepaldi, R. M. C., Monteiro, C., Peterlini, M. A. S., & Pedreira, M. da L. G. (2010). Hydrogen-Ion Potential of Antibiotics According to the Environment Factors Temperature and Luminosity . Revista Latino-Americana De Enfermagem, 18(2), 278-286. https://doi.org/10.1590/S0104-11692010000200020