A suplementação de arginina é efetiva em prevenir pré-eclâmpsia em gestantes?
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2022.184348Palavras-chave:
Gravidez, Arginina, Pré-eclâmpsia, Suplementação, Óxido nítricoResumo
Objetivo: O objetivo deste estudo foi revisar dados de ensaios clínicos randomizados para avaliar se a suplementação de L-Arginina é efetiva para reduzir a incidência de pré-eclâmpsia em gestantes com alto risco de desenvolver a doença.
Métodos: Realizamos uma revisão sistemática de ensaios clínicos randomizados, incluindo aqueles que compararam a suplementação de L-Arginina com placebo em gestantes de alto risco de desenvolvimento de pré-eclâmpsia, analisando a incidência de pré-eclâmpsia como desfecho principal. Os estudos foram selecionados do MEDLINE/ Pubmed, EMBASE/ Elsevier, LILACS/ BVS e Cochrane.
Resultados: Um total de 46 estudos foram identificados na busca primária. Após análise da elegibilidade, dos critérios de inclusão e de exclusão, dois artigos (que respeitaram em detalhes todas etapas de avaliação) foram incluídos na presente revisão. Foi realizada uma avaliação de risco de viés. A análise dos dados revelou que a incidência de pré-eclâmpsia foi significativamente menor em ambos os estudos, e nenhum efeito adverso importante foi relatado. As limitações deste estudo foram a falta de padronização entre os ensaios clínicos analisados e o número relativamente baixo de estudos incluídos.
Conclusão: A suplementação com L-Arginina parece reduzir a incidência de pré-eclâmpsia em gestantes de alto risco para seu desenvolvimento.
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Copyright (c) 2022 Gabriel Leite Citrangulo, Ana Luísa Scafura da Fonseca, Pedro Viana Diniz, João Pedro Torres Neiva Rodrigues, Denise Gasparetti Drumond
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
