Resistência Insulínica uma Disfunção Muito Além da Célula Beta
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2025.198061Palavras-chave:
Resistência à insulina, Hiperinsulinemia, Doença sistêmicaResumo
Introdução: A resistência à insulina (RI) é reconhecida como uma resposta biológica alterada à estimulação insulínica nos tecidos-alvo. A RI interfere no metabolismo da glicose, resultando em aumento da produção de insulina pelas células beta pancreáticas. A principal condição associada à RI em nosso meio é a obesidade, decorrente de fatores ambientais, especialmente a dieta, que ao longo dos anos foi progressivamente se consolidando em nossa civilização. Objetivo: Descrever a RI em diferentes órgãos e apresentar um projeto de via de sinalização. Métodos: Utilizou-se a base de dados PubMed para busca de artigos de revisão sobre resistência à insulina. Os dados referentes à via de sinalização foram selecionados mediante agregação de referências provenientes da Enciclopédia de Genes e Genomas de Kyoto (KEGG). Uma via de sinalização foi elaborada com base em artigos científicos sobre RI, demonstrando os diversos mecanismos envolvidos. O servidor KEGG foi empregado para explorar as interações proteína-proteína e elaborar o diagrama da via de sinalização. O mapeamento da via de sinalização foi realizado com o software PathVisio, adaptado ao modelo da base de dados KEGG PATHWAY: https://www.genome.jp/pathway/map0493 . Resultados: Foram selecionados artigos da base de dados PubMed que incluíam os termos "resistência à insulina" e "via de sinalização". Com base em artigos validados pela base de dados, optou-se por vias bem fundamentadas, obtendo-se uma descrição representativa dessas vias. Contigs de reprodução obtidos da base de dados KEGG permitiram projetar a via de sinalização de biomoléculas que levam à RI. Assim, a atuação conjunta de múltiplos mecanismos libera fatores que participam do desenvolvimento da RI. Conclusão: A interação entre múltiplos mecanismos e as interações moleculares são fatores importantes no desenvolvimento da RI em diversos órgãos e sistemas.
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Copyright (c) 2025 Luis Jesuino Oliveira Andrade, Luís Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Gabriela Correia Matos de Oliveira
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
