Trigger receptor expressed in myeloid cell type-1(TREM-1) as a biomarker of systemic inflammatory response syndrome (SIRS) in pediatrics
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2024.206940Palabras clave:
TREM-1, SIRS, Child, BiomarkerResumen
Objective: to determine the validity of TREM-1 as a SIRS biomarker in pediatric patients. Method:
systematic review, according to PRISMA, of studies published until October 2022 indexed in the VHL, Cochrane Library, PubMed/MEDLINE and Science Direct databases. The search strategy included the descriptors: TREM-1; SIRS; Child; Biomarker. Registration number PROSPERO CRD: 42022381838. Results: four studies comprising 2.353 patients aged 11 months to 18 years were included, with SIRS being present in 75% of these. Cutoff values ranged from 18.7 pg/mL to > 629 pg/mL. The results support a role for TREM-1 as a diagnostic tool for pediatric SIRS, but cannot be considered conclusive as a quantitative synthesis was not possible due to heterogeneity in study design. Conclusion: we conclude a potential use of TREM-1 in the pediatric population, specifically for the diagnosis of SIRS, with a good perspective in cardiac surgerythrough its elevation after surgery. However, it was not possible to establish a cut-off point, but rather to determine the possibility of its use for stratifying mortality risk, compared to baseline values, when the patient has SIRS.
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Derechos de autor 2024 João Victor Batista Cabral, Thaysa Maria Gama Albuquerque Leão de Menezes, Maria Mariana Barros Melo da Silveira, Amanda Tavares Xavier, Leuridan Cavalcante Torres, Dário Celestino Sobral Filho, Dinaldo Cavalcanti de Oliveira
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
