Composição da microbiota intestinal de gestantes e sua influência na ocorrência de desfechos perinatais adversos
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2025.217616Palavras-chave:
Microbioma, Gravidez, Assistência perinatalResumo
Objetivo: Investigar a associação entre a composição da microbiota intestinal em mulheres grávidas e a incidência de desfechos perinatais adversos com base em uma revisão sistemática. Métodos: A busca foi realizada nas bases de dados PubMed, Embase, Lilacs, Scopus e Web of Science. Um protocolo formal foi registrado no banco de dados PROSPERO (número de registro CRD42023470580). A qualidade dos estudos selecionados foi avaliada com base no Manual do Revisor do Instituto Joanna Briggs. Resultados: No total, foram identificados 7.393 artigos após a busca, e onze estudos foram selecionados para a presente revisão. O tamanho da amostra variou de 16 a 1.479 mulheres, e a idade cronológica dos participantes variou de 20 a 40 anos. Para a análise da microbiota intestinal, todos os artigos utilizaram amostras fecais, onde ocorreu a extração genética de ácidos nucleicos, como o ácido desoxirribonucleico (DNA) e ácido ribonucleico (RNA), e o sequenciamento de genes específicos a partir das fezes. Oito desfechos diferentes foram identificados, incluindo óbito fetal, circunferência abdominal fetal, crescimento intrauterino, comprimento femoral, peso, circunferência cefálica, nascimento prematuro e ganho de peso gestacional. Esses desfechos foram associados a mais de trinta cepas intestinais, tais como aquelas das famílias Eubacteriaceae, Lachnospiraceae, Ruminococcaceae e Parabacteroides, e do gênero Streptococcus. Conclusão: Esta revisão destacou a existência de uma associação entre a microbiota intestinal e desfechos perinatais adversos, tais como óbito fetal, circunferência abdominal fetal, crescimento intrauterino, comprimento femoral, peso, circunferência cefálica e nascimento prematuro, com mais de trinta cepas de bactérias intestinais.
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Copyright (c) 2025 Thiago Marques Wanderley, Bianca Gomes de Gomes de Souza, Tauane Alves Dutra, Danielle Alice Vieira da Silva, Marilene Brandão Tenório Fragoso, Nassib Bezerra Bueno, Alane Cabral Menezes de Oliveira
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
