Intestinal microbiota composition in pregnant women and its influence on the incidence of adverse perinatal outcomes
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2025.217616Palabras clave:
Intestinal microbiology, Pregnancy, Perinatal careResumen
Objective: Investigating the association between intestinal microbiota composition in pregnant women and incidence of adverse perinatal outcomes based on a systematic review. Methods: The search was carried out in PubMed, Embase, Lilacs, Scopus and Web of Science databases. A formal protocol was registered in PROSPERO database (registration number CRD42023470580). The quality of the selected studies was assessed based on the Joanna Briggs Institute Reviewer Manual. Results: In total, 7.393 articles were identified after the search and twelve studies were selected for the present review. Sample size ranged from 16 to 1.479 women, and participants' chronological age ranged from 20 to 40 years old. For the analysis of intestinal microbiota, all articles used fecal samples, with genetic extraction of nucleic acids such as deoxyribonucleic acid and ribonucleic acid, and sequencing of specific genes from fecal. Eight different outcomes were identified, including fetal demise, fetal abdominal circumference, intrauterine growth, femoral length, weight, head circumference, premature birth and gestational weight gain. These outcomes were associated with more than thirty (30) intestinal strains, such as those from the families Eubacteriaceae, Lachnospiraceae, Ruminococcaceae, Parabacteroides, and the genus Streptococcus. Conclusion: This review highlighted the existence of an association between intestinal microbiota and adverse perinatal outcomes, such as fetal demise, fetal abdominal circumference, intrauterine growth, femoral length, weight, head circumference, and premature birth, with over thirty strains of intestinal bacteria.
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Derechos de autor 2025 Thiago Marques Wanderley, Bianca Gomes de Gomes de Souza, Tauane Alves Dutra, Danielle Alice Vieira da Silva, Marilene Brandão Tenório Fragoso, Nassib Bezerra Bueno, Alane Cabral Menezes de Oliveira
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
