Effect of exclusion diet on the nutritional status of children and adolescents with cow’s milk protein allergy: a retrospective study
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https://doi.org/10.11606/issn.2176-7262.rmrp.2025.221748Palabras clave:
Food allergy, Milk hypersensitivity, Child nutrition disorders, Growth and developmentResumen
Objective: To describe the anthropometric parameters of patients with cow’s milk protein allergy (CMPA) followed up at a tertiary-care hospital before and after the initiation of a cow’s milk exclusion diet. Methods: Observational retrospective study of patients aged zero to 18 years with a diagnosis of CMPA who started specialized follow-up from 2015 until the first semester of 2021 at the food allergy outpatient clinic in a tertiary hospital in the interior of São Paulo. Results: The study included 278 patients and 3,629 weight measurements and 2,983 length/height measurements, allowing for the calculation of 2,985 Body Mass Index (BMI), with a mean age of symptom onset of 6.4 [± 11.7] months, mean age of cow’s milk exclusion diet start of 9.6 [± 14.2] months, and mean age of specialized care start of 3.1 [± 2.8] years. A significant decrease in Z-scores for weight, height, and BMI for age occurred after birth, with progressive recovery after the cow’s milk exclusion diet. The exclusion diet appears to have a greater impact on growth recovery than the initiation of specialized follow-up. In the long term, the same patients had a trend toward overweight and obesity. Conclusions: Children with CMPA showed progressive growth impairment up to the initiation of the cow’s milk exclusion diet, after which they exhibited recovery of all parameters. In the long term, there is an increase in the proportion of patients with overweight and obesity.
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Mousan G, Kamat D. Cow’s Milk Protein Allergy. Vol. 55, Clinical Pediatrics. SAGE Publications Inc.; 2016. p. 1054–63.
Jalonen T. Identical intestinal permeability changes in children with different clinical manifestations of cow’s milk allergy.
Majamaa H, Miettinen A, Laine S, Isolauri E. Clinical ami Expciiuicutal Alli’rs;v. Vol. 26. 1996.
Seppo L, Korpela R, Lönnerdal B, Metsäniitty L, Juntunen-Backman K, Klemola T, et al. A follow-up study of nutrient intake, nutritional status, and growth in infants with cow milk allergy fed either a soy formula or an extensively hydrolyzed whey formula 1-3 [Internet]. 2005. Available from: https://academic.oup.com/ajcn/article/82/1/140/4863331
Paganus A, Juntunen-Backman K, Savilahti E. Follow-up of nutritional status and dietary survey in children with cow’s milk allergy. Vol. 81, Acta Paediatr. 1992.
Vieira MC, Morais MB, Spolidoro JV, Toporovski MS, Cardoso AL, Araujo GT, et al. A survey on clinical presentation and nutritional status of infants with suspected cow’ milk allergy [Internet]. Vol. 10, BMC Pediatrics. 2010. Available from: http://www.biomedcentral.com/1471-2431/10/25
Isolauri E, Sütas Y, Salo MK, Isosomppi R, Kaila M. Elimination diet in cow’s milk allergy: Risk for impaired growth in young children. J Pediatr [Internet]. 1998 Jun;132(6):1004–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0022347698703993
Durban R, Groetch M, Meyer R, Coleman Collins S, Elverson W, Friebert A, et al. Dietary Management of Food Allergy. Immunol Allergy Clin N Am. 2021 May;41(2):233–270.
Tiainen J, Nuutinen O, Kalavainen M. Dieta e estado nutricional de crianças com alergia ao leite de vaca. Eur J Clin Nutr. 1995 Aug;49(8):605–12.
Vidmar SI, Cole TJ, Pan H. Standardizing Anthropometric Measures in Children and Adolescents with Functions for Egen: Update. The Stata Journal: Promoting communications on statistics and Stata. 2013 Jul 1;13(2):366–78.
Frizzo J, Rodrigues VCC, Speridião PGL, Morais MB. Evaluation of the complementary feeding practices, dietary intake, and nutritional status of infants on a cow’s milk protein elimination diet. J Pediatr (Rio J). 2022 May;98(3):256–63.
Jędrzejczyk M, Wąsowska-Królikowska K, Funkowicz M, Toporowska-Kowalska E. Analysis of nutritional status and diet in children with cow’s milk protein allergy on a milk elimination diet. Pediatria i Medycyna Rodzinna. 2019 Dec 31;15(4):387–92.
Camargo LS, Silveira JA, Taddei JA, Fagundes Neto U. Allergic proctocolitis in infants: analysis of the evolution of the nutritional status. Arq Gastroenterol. 2016 Dec;53(4):262–6.
Vandenplas Y, Dupont C, Eigenmann P, Heine RG, Høst A, Järvi A, et al. Growth in Infants with Cow’s Milk Protein Allergy Fed an Amino Acid-Based Formula. Pediatr Gastroenterol Hepatol Nutr. 2021;24(4):392.
Meyer R, Wright K, Vieira MC, Chong KW, Chatchatee P, Vlieg-Boerstra BJ, et al. International survey on growth indices and impacting factors in children with food allergies. Journal of Human Nutrition and Dietetics. 2019 Apr;32(2):175–84.
Maslin K, Dean T, Arshad SH, Venter C. Dietary variety and food group consumption in children consuming a cows’ milk exclusion diet. Pediatric Allergy and Immunology. 2016 Aug;27(5):471–7.
Maslin K, Dean T, Arshad SH, Venter C. Fussy eating and feeding difficulties in infants and toddlers consuming a cows’ milk exclusion diet. Pediatric Allergy and Immunology. 2015 Sep;26(6):503–8.
Rodrigues VC de C, Speridião P da GL, Sanudo A, Morais MB. Feeding difficulties in children fed a cows’ milk elimination diet. British Journal of Nutrition. 2022 Sep 28;128(6):1190–9.
Dong P, Feng J jing, Yan D yong, Lyu Y jing, Xu X. Children with cow’s milk allergy following an elimination diet had normal growth but relatively low plasma leptin at age two. Acta Paediatr. 2018 Jul;107(7):1247–52.
Salmivesi S, Paassilta M, Huhtala H, Nieminen R, Moilanen E, Korppi M. Changes in biomarkers during a six-month oral immunotherapy intervention for cow’s milk allergy. Acta Paediatr. 2016 Nov;105(11):1349–54.
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Derechos de autor 2025 Laura Cardoso Brentini, Patrícia Schiavotello Stefanelli, Laura Dresch Neumann, Gustavo Santos Paiva Laender Moura, Persio Roxo-Junior, Fabio Carmona

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.



