Trauma and sepsis metabolic response monitoring

Abstract

Sepsis, trauma, systemic inflammatory response syndrome and multiple organ dysfunction syndrome cause hypermetabolism, which is the principal factor for high mortality in critical ill intensive care unit patients. The hypermetabolism evolution, probably connected to the release of the mediators and metabolites, ends up impairing the metabolism of several organs. By the reasons mentioned above, and due to the extreme concern in understanding the metabolism in critical ill patients, this paper evaluates the different aspects in monitoring the physiological parameters in patients with metabolic stress. These aspects are the oxygen consumption, and the splanchnic perfusion, linked with the lactate plasma and the protein turnover by means of the intravenous infusion of 13 C-leucine (stable isotopes).