Vitamin E deficiency and associated factors among Brazilian school children
DOI:
https://doi.org/10.11606/issn.2176-7262.v53i4p424-429Keywords:
Child, Vitamin E Deficiency, Risk FactorsAbstract
Objective: Brazilian national data show a significant deficiency in pediatric vitamin E consumption, but there are very few studies evaluating laboratory-proven nutritional deficiency. The present study aimed to settle the prevalence of vitamin E deficiency (VED) and factors associated among school-aged children attended at a primary health unit in Ribeirão Preto (SP).
Methods: A cross-sectional study that included 94 children between 6 and 11 years old. All subjects were submitted to vitamin E status analysis. To investigate the presence of factors associated with VED, socioeconomic and anthropometric evaluation, determination of serum hemoglobin and zinc levels, and parasitological stool exam were performed. The associations were performed using Fisher's exact test.
Results: VED (α-tocopherol concentrations <7 μmol/L) was observed in seven subjects (7.4%). None of them had zinc deficiency. Of the total of children, three (3.2%) were malnourished, 12 (12.7%) were anemic, and 11 (13.5%) presented some pathogenic intestinal parasite. These possible risk factors, in addition to maternal-work, maternal educational level, and monthly income, were not associated with VED.
Conclusions: The prevalence of VED among school-aged children attended at a primary health unit was low. Zinc deficiency, malnutrition, anemia, pathogenic intestinal parasite, maternal-work, maternal educational level, and monthly income were not a risk factor for VED.
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References
Traber MG, Frei B, Beckman JS. Vitamin E revisited: do new data validate benefits for chronic disease prevention? Current Opinion in Internal Medicine. 2008;7:155-163.10.1097/mol.0b013e3282f2dab6
Schwenke DC. Nutrition and metabolism: α-Tocopherol to prevent cardiovascular disease – deficiency, dose, delivery, and developing context. Current Opinion in Lipidology. 2008;19:203-207.10.1097/mol.0b013e3282f8afc0
Oski FA, Barness LA. Vitamin E deficiency: A previously unrecognized cause of hemolytic anemia in the premature infant. The Journal of Pediatrics. 1967;70:211-220.10.1016/s0022-3476(67)80416-5
Baumgartner MR. Vitamin-responsive disorders. Handbook of Clinical Neurology: Elsevier; 2013. p. 1799-1810.
Feki M, Souissi M, Mebazaa A, editors. Vitamin E deficiency. Etiopathogenesis, clinical, histopathologic, and electrical features, and main etiologies. Annales de medecine interne; 2001.
Sapiejka E, Krzyzanowska-Jankowska P, Wenska-Chyzy E, Szczepanik M, Walkowiak D, Cofta S, et al. Vitamin E status and its determinants in patients with cystic fibrosis. Adv Med Sci. 2018;63:341-346.10.1016/j.advms.2018.04.001
Augusto RA, Cobayashi F, Cardoso MA. Associations between low consumption of fruits and vegetables and nutritional deficiencies in Brazilian schoolchildren. Public Health Nutr. 2015;18:927-935.10.1017/s1368980014001244
Hoeft B, Weber P, Eggersdorfer M. Micronutrients - a Global Perspective on Intake, Health Benefits and Economics. International Journal for Vitamin and Nutrition Research. 2012;82:316-320.10.1024/0300-9831/a000125
de Castro MA, Verly E, Fisberg M, Fisberg RM. Children's nutrient intake variability is affected by age and body weight status according to results from a Brazilian multicenter study. Nutrition Research. 2014;34:74-84.https://doi.org/10.1016/j.nutres.2013.09.006
WHO Expert Committee on Drug Dependence: Twenty-eighth report. PsycEXTRA Dataset: American Psychological Association (APA); 1993.
Almeida CA, Ricco RG. Avaliação do estado nutricional com ênfase à antropometria. Pediatria (Säo Paulo). 1998;20:385-398,
Jelliffe DB, Organization WH. Evaluación del estado de nutrición de la comunidad (con especial referencia a las encuestas en las regiones en desarrollo. 1968,
Farrell PM, Levine SL, Murphy M, Adams AJ. Plasma tocopherol levels and tocopherol-lipid relationships in a normal population of children as compared to healthy adults. The American journal of clinical nutrition. 1978;31:1720-1726,
WHO. Iron deficiency anemia. assessment, prevention, and control. Geneva: World Health Organization; 2001.
Kapil U, Bhadoria A, Sareen N. Correlates of zinc deficiency among children in age group of six to sixty months belonging to the low-income group. Journal of Family and Community Medicine. 2013;20:139.10.4103/2230-8229.114778
Hoffman WA, Pons JA, Janer JL. The sedimentation-concentration method in schistosomiasis mansoni. 1934,
Faust EC, Tobie J, Thomen LF, Sawitz W, D'Antoni JS, Peres C, et al. A Critical Study of Clinical Laboratory Technics for the Diagnosis of Protozoan Cysts and Helminth Eggs in Feces 1. The American Journal of Tropical Medicine and Hygiene. 1938;s1-18:169-183.10.4269/ajtmh.1938.s1-18.169
WHO. WHO Expert Committee on Physical Status: the use and interpretation of anthropometry. Geneva: World Health Organization; 1995.
Jilani T, Iqbal MP. Vitamin E deficiency in South Asian population and the therapeutic use of alpha-tocopherol (Vitamin E) for correction of anemia. Pakistan Journal of Medical Sciences. 2018;34:1571,
Dror DK, Allen LH. Vitamin E deficiency in developing countries. Food and nutrition bulletin. 2011;32:124-143,
Kim Y-N, Lora KR, Giraud DW, Driskell JA. Nonsupplemented Children of Latino Immigrants Have Low Vitamin E Intakes and Plasma Concentrations and Normal Vitamin C, Selenium, and Carotenoid Intakes and Plasma Concentrations. Journal of the American Dietetic Association. 2006;106:385-391.10.1016/j.jada.2005.12.010
Looker AC, Underwood BA, Wiley J, Fulwood R, Sempos CT. Serum alpha-tocopherol levels of Mexican Americans, Cubans, and Puerto Ricans aged 4–74 y. The American Journal of Clinical Nutrition. 1989;50:491-496.10.1093/ajcn/50.3.491
Drewel B, Giraud D, Davy S, Driskell J. Less than adequate vitamin E status observed in a group of preschool boys and girls living in the United States☆. The Journal of Nutritional Biochemistry. 2006;17:132-138.10.1016/j.jnutbio.2005.06.003
Giraud, Kim, Cho, Driskell. Vitamin E Inadequacy Observed in a Group of 2- to 6-Year-Old Children Living in Kwangju, Republic of Korea. International Journal for Vitamin and Nutrition Research. 2008;78:148-155.10.1024/0300-9831.78.3.148
Food, Staff NB, Antioxidants PoD, Staff IoM. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids: A Report of the Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and of Interpretation and Use of Dietary Reference Intakes and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine: National Academies Press; 2000.
Wallert M, Börmel L, Lorkowski S. Inflammatory Diseases and Vitamin E–What Do We Know and Where Do We Go? Molecular Nutrition & Food Research. 2000097
Saran Netto A, Salles MSV, Roma Júnior LC, Cozzolino SMF, Gonçalves MTM, Freitas Júnior JE, et al. Increasing Selenium and Vitamin E in Dairy Cow Milk Improves the Quality of the Milk as Food for Children. Nutrients. 2019;11.10.3390/nu11061218
Clarke MW, Burnett JR, Croft KD. Vitamin E in Human Health and Disease. Critical Reviews in Clinical Laboratory Sciences. 2008;45:417-450.10.1080/10408360802118625
Souza N, Dutra de Oliveira J. Estudo experimental sobre o valor nutritivo de misturas de arroz e feijão. Rev Bras Pesq Méd Biol. 1969;2:175-180,
Veiga EV, Vannucchi H, Marchini JS, Dutra de Oliveira JE. The nutritive value of a rice and soybean diet for adults. Nutrition Research. 1985;5:577-583.10.1016/s0271-5317(85)80238-4
Ferraz IS, Daneluzzi JC, Vannucchi H. Vitamin A deficiency in children aged 6 to 24 months in Sao Paulo State, Brazil. Nutrition Research. 2000;20:757-768.10.1016/s0271-5317(00)00177-9
Ferraz IS, Daneluzzi JC, Vannucchi H, Jordão AA, Ricco RG, Del Ciampo LA, et al. Detection of vitamin A deficiency in Brazilian preschool children using the serum 30-day dose–response test. European Journal of Clinical Nutrition. 2004;58:1372-1377.10.1038/sj.ejcn.1601978
Bunk MJ, Dnistrian AM, Schwartz MK, Rivlin RS. Dietary Zinc Deficiency Decreases Plasma Concentrations of Vitamin E. Experimental Biology and Medicine. 1989;190:379-384.10.3181/00379727-190-42876
Muniz PT, Ferreira MU, Ferreira CS, Conde WL, Monteiro CA. Intestinal parasitic infections in young children in São Paulo, Brazil: prevalences, temporal trends and associations with physical growth. Annals of Tropical Medicine & Parasitology. 2002;96:503-512.10.1179/000349802125001311
Harvey TV, Tang AM, da Paixao Sevá A, Albano dos Santos C, Santos Carvalho SM, Magalhães da Rocha CMB, et al. Enteric parasitic infections in children and dogs in resource-poor communities in northeastern Brazil: Identifying priority prevention and control areas. PLOS Neglected Tropical Diseases. 2020;14:e0008378.10.1371/journal.pntd.0008378
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Copyright (c) 2020 Viviane Imaculada do Carmo Custódio, Carlos Alberto Nogueira-de-Almeida, Luiz Antonio Del Ciampo, Fábio da Veiga Ued, Ane Cristina Fayão Almeida, Rodrigo José Custódio, Alceu Afonso Jordão Jr, Júlio César Daneluzzi, Ivan Savioli Ferraz
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