Prevalence and factors associated with potentially inappropriate medications and drug interactions inelderly individuals in a primary health care setting
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2024.211366Keywords:
Elderly health, Medication prescriptions, List of potentially inappropriate medications, Drug interactions, Primary health careAbstract
Objective: To verify the prevalence and factors associated with drug interactions and potentially
inappropriate medications used by elderly people assisted by a Basic Health Unit. Methods: Cross-sectional study, carried out with 236 elderly people aged ≥ 60 years, assisted by the Family Health Strategy. The dependent variables were the presence of potentially inappropriate
medications and drug interactions, using the Beers criteria and the systematic organization
Anatomical therapeutic Chemical . The independent variables were age, sex, color, marital status, education, contribution to family income, presence of smoking, presence of alcohol consumption, living alone, leaving home alone, practicing physical activity, practicing leisure activities, practicing activities offered by UBS, self-perceived health, multimorbidity and presence of polypharmacy. Descriptive analyzes were carried out and associative analyzes were carried out using Pearson’s Chi -square test. Results: 27.5% of the elderly used at least 1 potentially inappropriate medication, being associated with age greater than or equal to 75 years (38.5%), female sex (32.4%), white color (40.3%) , absence of smoking (44.4%), absence of leisure activities (31.8%), presence of multimorbidities (34.4%) and practice of polypharmacy (43.8%). Drug interactions were present in 18.2% of the sample and were associated with the female gender (22.7%), practicing activities at the UBS (31.4%), self-perception of health as negative (23.9%), presence multimorbidity (25.3%) and presence of polypharmacy (42.7% ) . The main potentially inappropriate medication was omeprazole and the main drug interaction was simvastatin with amlodipine. Conclusion: The presence of inappropriate medications and undue drug interactions can cause significant functional loss in the elderly, with adverse effects, new diseases or cognitive decline, giving rise to a cascade of prescriptions. Coordination of care for elderly people is necessary to optimize pharmacotherapy and avoid unfavorable outcomes.
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Copyright (c) 2024 Glenda Pereira Lima Oliveira, Aldren Thomazini Falçoni Júnior, Gracielle Pampolim, Luciana Carrupt Machado Sogame
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