THE INVOLVEMENT OF THE COMPLEMENT SYSTEM IN THE PROCESSES IN ATHEROGENESIS

Authors

  • Ana Paula Landi Librandi
  • Ana Isabel Assis Pandochi Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo

DOI:

https://doi.org/10.11606/issn.2176-7262.v41i3p312-326

Keywords:

Complement System Proteins. Atherosclerosis. Inflammation. Complement Membrane Attack Complex. Atherogenesis.

Abstract

Atherosclerosis has been considered a chronic inflammatory illness induced by macrophage activation, T lymphocyte and complement system. This system corresponds to a group of plasma and membrane proteins, which are activated by a cascade of interactions that result in the production of some pro-inflammatory molecules. Although it is one of the effector mechanisms of the innate immune system, in certain circumstances, the system complement can itself contribute for "triggering" cardiovascular diseases. This review contains a brief description of the complement cascade and the processes of atherogenesis as well as the involvement of immunological factors, mainly the complement system activation on patogenesis of atherosclerosis.

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Author Biographies

  • Ana Paula Landi Librandi

     

    Doutora em Ciências Farmacêuticas,

  • Ana Isabel Assis Pandochi, Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo

     

    Docente. Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo

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Published

2008-09-30

Issue

Vol. 41 No. 3 (2008)

Section

Review

License

 

 

How to Cite

1.
Librandi APL, Pandochi AIA. THE INVOLVEMENT OF THE COMPLEMENT SYSTEM IN THE PROCESSES IN ATHEROGENESIS. Medicina (Ribeirão Preto) [Internet]. 2008 Sep. 30 [cited 2024 May 18];41(3):312-26. Available from: https://revistas.usp.br/rmrp/article/view/276