OTOTOXYCITY, OTOPROTECTION AND SELF DEFENSE OF THE COCLEAR OUTER HAIR CELLS

Authors

  • Miguel A. Hyppolito Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo -FMRP/USP
  • José Antonio A. Oliveira Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo -FMRP/USP

DOI:

https://doi.org/10.11606/issn.2176-7262.v38i3/4p279-289

Keywords:

Ototoxicity, Aminoglicosides. Cisplatin. Otology. Drug Toxicity.

Abstract

Ototoxicity are affection caused by side effects of medicaments with irreversible auditory and bilateral neurossensorial hearing loss to frequencies 250 to 8000 Hz, with or without vertigo or dizziness. Most of the studies on this area are reffered to aminoglicosides and antineoplastic drugs like cisplatin, used for cancer treatment in children and adults. Reports recognize some drugs that are associated with this drugs to obtain an otoprotector effect. The ototoxicity mechanisms of aminoglicosides and cisplatin are related to injury of conduct the hair cell oxidation mechanism, with particular injury to outer hair cells. Other possibility are a self-defense mechanism of outer hair cells reported by some studies.

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Author Biographies

  • Miguel A. Hyppolito, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo -FMRP/USP

    Docente. Divisão de Otorrinolaringologia. Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo -FMRP/USP

  • José Antonio A. Oliveira, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo -FMRP/USP

    Docente. Divisão de Otorrinolaringologia. Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo -FMRP/USP

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Published

2005-12-30

Issue

Vol. 38 No. 3/4 (2005)

Section

Capítulos

License

 

 

How to Cite

1.
Hyppolito MA, Oliveira JAA. OTOTOXYCITY, OTOPROTECTION AND SELF DEFENSE OF THE COCLEAR OUTER HAIR CELLS. Medicina (Ribeirão Preto) [Internet]. 2005 Dec. 30 [cited 2024 May 31];38(3/4):279-8. Available from: https://revistas.usp.br/rmrp/article/view/461