Late complications of hematopoietic stem cell transplantation

Abstract

Significant advances in hematopoietic stem cell transplantation (HSCT) has resulted in a large cohort of patients surviving more than 20 years after transplantation for hematological and malignant disorders. The increased number of long-term survivors has provided an unique opportunity to study the late effects of the HSCT. This review describes the late complications of HSCT related to the conditioning regimen, recurrence of primary malignancy and transplant-related toxicity with an emphasis on diagnosis and treatment of chronic graft-versushost disease.