Clearance of immune complexes

role of complement and polymorphonuclear neutrophils

Authors

  • Cleni Mara Marzocchi-Machado Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto
  • Yara Maria Lucisano-Valim Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto

DOI:

https://doi.org/10.11606/issn.2176-7262.v30i2p234-242

Keywords:

Antigen-Antibody Complex, Complement, Neutrophils, Immune Complex Diseases

Abstract

The complement system plays an important role in the transport and elimination of circulating immune complexes (IC). However, there are circunstances where the envolved mechanisms fail, leading to deposition of IC at specific organs. The deposited complexes stimulate phagocytosis by polymorphonuclear neutrophils, with production of oxygen radicals and release of lysossomal enzymes, thus contributing to tissular injury. In this review, we discuss the role of complement and neutrophils in pathogenesis of immune complexes diseases.

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Published

1997-06-30

Issue

Vol. 30 No. 2 (1997)

Section

Review

License

 

 

How to Cite

1.
Marzocchi-Machado CM, Lucisano-Valim YM. Clearance of immune complexes: role of complement and polymorphonuclear neutrophils. Medicina (Ribeirão Preto) [Internet]. 1997 Jun. 30 [cited 2024 May 21];30(2):234-42. Available from: https://revistas.usp.br/rmrp/article/view/880