COVID19: uncovering interindividual variability for tailoring appropriate therapeutic interventions
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2022.180873Keywords:
COVID-19, Severe acute respiratory syndrome, Immunoinflammatory response, Cytokine storm, SARS-CoV2, Treatment outcomeAbstract
The severity of SARS-CoV2 infection, Covid19 disease, should account for the diversity of human individual immunoinflammatory responses. Serum immunological markers during Covid19 illness may lead to individualized therapeutics with better outcomes. Efficient treatment for Covid19 may require: 1) early disease detection, 2) combined
drug therapy for 3) targeting the virus replication cycle, and 4) individualized drug treatment for specific immunoinflammatory human profile responses administered in a 5) timely manner. Covid19 is unlikely to be the last emergent human disease with fast pandemic potential. Gathering knowledge on the individual human host profiles
of immunoinflammatory responses is an opportunity that could lead us to understand individual differences in response to infection at the individual and population level, paving the way to faster, more efficient strategies to tackle upcoming infectious diseases. This is a position paper based on an integrative non-exhaustive literature revision.
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Copyright (c) 2022 Maria Goreti Rosa Freitas, Carolina Muruci-Cruz, Luiz Fernando Dale, Luis Eduardo da Cruz, Jorge Kalil
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