Análisis bioquímico del estrés oxidativo y del sistema purinérgico en gestantes con diabetes mellitus gestacional
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2023.193812Palabras clave:
Pregnancy complications, Gestational diabetes, Oxidative stress , Antioxidants , PurinesResumen
Background: Pregnancy is characterized as a physiological period with greater sensitivity to insulin resistance and changes in oxidative stress. Purinergic signaling is directly related to diabetes, as this condition modifies the concentration of extracellular ATP and the level of degradation of ATP to adenosine. Objective: Analyze oxidative stress and the purinergic system in pregnant women with Gestational Diabetes Mellitus (GDM) and compare them with low-risk pregnant women (LR). Materials and methods: The research was of a quantitative approach of an experimental nature. The study was carried out at the Clínica da Mulher, which serves high-risk pregnant women, and at the Family Health Centers, which serves low-risk pregnant women, both located in Chapecó, Santa Catarina, Brazil. Results: From the analysis, it was observed that oxidative stress was increased in pregnant women in LR compared to pregnant women with GDM by increasing the concentration of TBARS and reducing the concentration of Carbonyl Protein in pregnant women with LR. Regarding the purinergic system, there was a significant decrease in the hydrolysis of the nucleotides ATP, ADP, and AMP in pregnant women with GDM, and a significant increase in the hydrolysis of ADA, also in pregnant women with GDM. Conclusion: Therefore, pregnant women with GDM have less oxidative stress compared to pregnant women in LR concerning TBARS and Carbonyl Protein markers, thus allowing a greater antioxidant defense mechanism. Furthermore, concerning the purinergic system, there is an increase in the activity of ADA, which is directly related to the immunosuppression process, a necessary condition for the protection of the fetus during the gestational period.
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Derechos de autor 2023 Bruna Laís Hardt, Bianca Devens Oliveira, Maiara Vanusa Guedes Ribeiro, Matheus Ribeiro Bizuti, Aline Mânica, Érica de Brito Pitilin, Margarete Dulce Bagatini, Débora Tavares Resende e Silva
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
