Progresión de la esclerosis múltiple recurrente-remitente a pesar de la nueva era de las drogas
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2022.196823Palabras clave:
Multiple sclerosis, Disease progression, TherapeuticsResumen
Objective. The present study aims to evaluate the conditions associated with the progression of Multiple Sclerosis (MS) and patients' dysfunctions. Methods. We perform a retrospective longitudinal analytical observational study in 46 patients with MS from a polyclinic at Rio de Janeiro, Brazil. We used the Expanded Disability Status Scale (EDSS) to rank the patients according to their disability and establish correlation with risk factors, treatment and time of disease. Results. Of 46 patients, 69.6% were female and 67.4% were white. Patients with fewer functional systems affected at the beginning of the disease had a longer time for disease progression, according to EDSS. Low efficacy drugs led to a high rate of discontinuation of the treatment. Patients who used a continuously treatment took longer to reach higher EDSS values than those who discontinued treatment. Conclusion. Despite the control of MS with high effective drugs, there is still some disability for the patient. The factors that influenced the progression of the disability were: multiple symptoms at the beginning of the disease, more than 30 years old at the beginning of the MS, delay in diagnosis and initiation of treatment, among others.
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Derechos de autor 2022 Gutemberg Augusto Cruz dos Santos, Gabriel Etienne Brito de Salles, Milenna Grisoli Martins da Silva, Roxanne Cabral Pinto Santos
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
