Towards a unified theory of health-disease: II. Holopathogenesis
DOI:
https://doi.org/10.1590/S0034-8910.2014048005196Abstract
This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.Downloads
Published
2014-04-01
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Special Article
How to Cite
Almeida Filho, N. (2014). Towards a unified theory of health-disease: II. Holopathogenesis. Revista De Saúde Pública, 48(2), 192-205. https://doi.org/10.1590/S0034-8910.2014048005196