Mortality and years of life lost related to adverse drug events in Brazil
DOI:
https://doi.org/10.11606/s1518-8787.2024058005458Keywords:
Drug-Related Side Effects and Adverse Reactions, Pharmacoepidemiology, Databases, PharmaceuticalAbstract
OBJECTIVE: To assess regional and national mortality and years of life lost (YLL) related to adverse drug events in Brazil. METHODS: This is an ecological study in which death records from 2009 to 2018 from the Mortality Information System were analyzed. Codes from the International Classification of Diseases 10th revision (ICD-10) that indicated drugs as the cause of death were identified. The number of deaths and the YLL due to adverse drug events were obtained. Crude, ageand gender-specific, and age-adjusted mortality rates and YLL rates per 100,000 inhabitants were formed by year, age group, gender, and Brazilian Federative Unit. Rate ratios were calculated by comparing rates from 2009 to 2018. A joinpoint regression model was applied for temporal analysis. RESULTS: For the selected ICD-10 codes, a total of 95,231 deaths and 2,843,413 YLL were recorded. Mortality rates from adverse drug events increased by a mean of 2.5% per year, and YLL rates increased by 3.7%. Increases in rates were observed in almost all age groups for both genders. Variations in rates were found between Federative Units, with the highest age-adjusted mortality and YLL rates occurring in the Distrito Federal. CONCLUSIONS: The numbers and rates of deaths and YLL increased during the study period, and variations in rates of deaths and YLL were observed between Brazilian Federative Units. Information on multiple causes of death from death certificates can be useful for quantifying adverse drug events and analyzing them geographically, by age and by gender.
References
Roughead EE, Semple SJ, Rosenfeld E. The extent of medication errors and adverse drug reactions throughout the patient journey in acute care in Australia. Int J Evid-Based Healthc. 2016 Sep;14(3):113-22. https://doi.org/10.1097/XEB.0000000000000075
Alhawassi TM, Krass I, Bajorek BV, Pont LG. A systematic review of the prevalence and risk factors for adverse drug reactions in the elderly in the acute care setting. Clin Interv Aging. 2014 Dec;9:2079-86. https://doi.org/10.2147/CIA.S71178
Agency for Healthcare Research and Quality. Medication errors and adverse drug events. Medication errors and adverse drug events. PSNet. 2019 Sep 7 [cited 2020 Dec 16]. Available from https://psnet.ahrq.gov/primer/medication-errors-and-adverse-drug-events
Shepherd G, Mohorn P, Yacoub K, May DW. Adverse drug reaction deaths reported in United States vital statistics, 1999-2006. Ann Pharmacother. 2012 Feb;46(2):169-75. https://doi.org/10.1345/aph.1P592
Buchanich JM, Balmert LC, Pringle JL, Williams KE, Burke DS, Marsh GM. Patterns and trends in accidental poisoning death rates in the US, 1979-2014. Prev Med. 2016 Aug;89:317-23. https://doi.org/10.1016/j.ypmed.2016.04.007
McGuire AR, DeJoseph ME, Gill JR. An approach to iatrogenic deaths. Forensic Sci Med Pathol. 2016 Mar;12(1):68-80. https://doi.org/10.1007/s12024-016-9745-5
Goldstein E. Rise in mortality involving poisoning by medicaments other than narcotics, including poisoning by psychotropic drugs in different age/racial groups in the US. PLoS One. 2019 Jul;14(7):e0219711. https://doi.org/10.1371/journal.pone.0219711
Zhu J, Hou W, Xu Y, Ji F, Wang G, Chen C, et al. Antipsychotic drugs and sudden cardiac death: A literature review of the challenges in the prediction, management, and future steps. Psychiatry Res. 2019 Nov;281:112598. https://doi.org/10.1016/j.psychres.2019.112598
Weeke P, Jensen A, Folke F, Gislason GH, Olesen JB, Andersson C, et al. Antidepressant use and risk of out-of-hospital cardiac arrest: a nationwide case-time-control study. Clin Pharmacol Ther. 2012 Jul;92(1):72-9. https://doi.org/10.1038/clpt.2011.368
Jiang Y, Ranney ML, Perez B, Viner-Brown S. Burden of violent death on years of life lost in Rhode Island, 2006-2013. Am J Prev Med. 2016 Nov;51(5 Suppl 3):S251-9. https://doi.org/10.1016/j.amepre.2016.08.004
Castillo-Rodríguez L, Díaz-Jiménez D, Castañeda-Orjuela C, De la Hoz-Restrepo F. Years of Life Lost (YLL) in Colombia 1998-2011: overall and avoidable causes of death analysis. PLoS One. 2015 May;10(5):e0125456. https://doi.org/10.1371/journal.pone.0125456
Martinez R, Soliz P, Caixeta R, Ordunez P. Reflection on modern methods: years of life lost due to premature mortality-a versatile and comprehensive measure for monitoring non-communicable disease mortality. Int J Epidemiol. 2019 Aug;48(4):1367-76.
https://doi.org/10.1093/ije/dyy254
Mota DM, Melo JR, de Freitas DR, Machado M. [Profile of mortality by intoxication with medication in Brazil, 1996-2005: portrait of a decade]. Cien Saude Colet. 2012 Jan;17(1):61-70. Portuguese. https://doi.org/10.1590/S1413-81232012000100009
Ministério da Saúde (BR). Sistema de Informação sobre Mortalidade (SIM). [cited 2020 July 15]. Available from: http://www2.datasus.gov.br/DATASUS/index.php?area=0901&item=1&acao=26
Instituto Brasileiro de Geografia e Estatística. Brazilian Population projections. 2018 [cited 2020 July 15]. Available from: https://www.ibge.gov.br/estatisticas/sociais/populacao/9109-projecao-da-populacao.html?=&t=downloads
World Health Organization. International statistical classification of diseases and related health problems 10th revision. 2019 [cited 2020 June 26]. Available from: https://icd.who.int/browse10/2019/en
Mota DM, Vigo A, Kuchenbecker RS. [Recommendation of ICD-10 codes for surveillance of adverse drug reactions and drug intoxication]. Cienc. Saude Coletiva 2018;23(9):3041-54. Portuguese. https://doi.org/10.1590/1413-81232018239.20692016
Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M. AGE Standardization of rates: a new WHO standard. Geneve: World Health Organization; 2001.
National Cancer Institute. Division of Cancer Control & Population Sciences. Surveillance Research Program. 2020 [cited 2020 July 20]. Available from: https://surveillance.cancer.gov/joinpoint/
Donaldson LJ, Kelley ET, Dhingra-Kumar N, Kieny MP, Sheikh A. Medication without harm: WHO’s Third Global Patient Safety Challenge. Lancet. 2017 Apr;389(10080):1680-1. https://doi.org/10.1016/S0140-6736(17)31047-4
Chyka PA. How many deaths occur annually from adverse drug reactions in the United States? Am J Med. 2000 Aug;109(2):122-30. https://doi.org/10.1016/S0002-9343(00)00460-5
Wester K, Jönsson AK, Spigset O, Druid H, Hägg S. Incidence of fatal adverse drug reactions: a population based study. Br J Clin Pharmacol. 2008 Apr;65(4):573-9. https://doi.org/10.1111/j.1365-2125.2007.03064.x
Santos GA, Boing AC. [Hospitalizations and deaths from drug poisoning and adverse reactions in Brazil: an analysis from 2000 to 2014]. Cad Saude Publica. 2018 Jun;34(6):e00100917. Portuguese. https://doi.org/10.1590/0102-311x00100917
Miguel A, Marques B, Freitas A, Lopes F, Azevedo L, Pereira AC. Detection of adverse drug reactions using hospital databases-a nationwide study in Portugal. Pharmacoepidemiol Drug Saf. 2013 Aug;22(8):907-13. https://doi.org/10.1002/pds.3468
Wester K, Jönsson A, Spigset O, Hägg S. Spontaneously reported fatal suspected adverse drug reactions: a 10-year survey from Sweden. Pharmacoepidemiol Drug Saf. 2007 Feb;16(2):173-80. https://doi.org/10.1002/pds.1263
Davies EA, O’Mahony MS. Adverse drug reactions in special populations – the elderly. Br J Clin Pharmacol. 2015 Oct;80(4):796-807. https://doi.org/10.1111/bcp.12596
Angamo MT, Chalmers L, Curtain CM, Bereznicki LR. Adverse-drug-reaction-related hospitalisations in developed and developing countries: a review of prevalence and contributing factors. Drug Saf. 2016 Sep;39(9):847-57. https://doi.org/10.1007/s40264-016-0444-7
Okumura Y, Sakata N, Takahashi K, Nishi D, Tachimori H. Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: an exploratory descriptive study using a nationwide claims database. J Epidemiol. 2017 Aug;27(8):373-80. https://doi.org/10.1016/j.je.2016.08.010
Sunshine JE, Meo N, Kassebaum NJ, Collison ML, Mokdad AH, Naghavi M. Association of adverse effects of medical treatment with mortality in the United States: A secondary analysis of the global burden of diseases, injuries, and risk factors study. JAMA Netw Open.
Jan;2(1):e187041. https://doi.org/10.1001/jamanetworkopen.2018.7041
Luan G, Yin P, Li T, Wang L, Zhou M. The years of life lost on cardiovascular disease attributable to ambient temperature in China. Sci Rep. 2017 Oct;7(1):13531. https://doi.org/10.1038/s41598-017-13225-2
Published
Issue
Section
License
Copyright (c) 2024 Lunara Teles Silva, Ana Carolina Figueiredo Modesto, Rodrigo Alves de Oliveira, Rita Goreti Amaral, Flavio Marques Lopes
This work is licensed under a Creative Commons Attribution 4.0 International License.
