Oral clefts: a case-control study

Authors

  • Leonor de Castro Monteiro Loffredo Universidade Estadual Paulista; Faculdade de Odontologia de Araraquara; Departamento de Odontologia Social
  • José Maria Pacheco de Souza Universidade de São Paulo; Faculdade de Saúde Pública; Departamento de Epidemiologia
  • João Yunes Universidade de São Paulo; Faculdade de Saúde Pública; Departamento de Epidemiologia
  • José Alberto de Souza Freitas Universidade de São Paulo; Hospital de Pesquisa e Reabilitação de Lesões Lábio Palatais de Bauru
  • Wilza Carla Spiri Universidade de São Paulo; Faculdade de Saúde Pública; Departamento de Epidemiologia

DOI:

https://doi.org/10.1590/S0034-89101994000300009

Keywords:

Cleft lip^i2^sepidemiol, Cleft palate^i2^sepidemiol, Risk factors

Abstract

This study relates to a case-control analysis for the purpose of verifying the association between oral clefts and possible risk factors. The analysed variables were: place of mother's residence (urban/ rural), pollution, parental diseases, mother's diseases during the first four months of pregnancy, intake of drugs related to this period, heredity, smoking habits, alcohol consumption and X-ray examinations during pregnancy or X-ray examinations prior to preganacy. There were 450 cases of clefts of whom 354 had a cleft lip with or without cleft palate and 96 had a cleft palate. The relative risk (RR) for each variable by was estimated points and at a 95% of confidence interval and multivariate analysis was applied. As regards cleft lip with or without cleft palate, the risk factors are heredity (RR = 4.96), epilepsy in the mother (RR = 2.39) and the intake of drugs such as anti-inflammatory substance in the first four months of pregnancy (RR = 2.59). Related to cleft palate, the risk factors are heredity (RR = 2.82) and pollution (RR = 2.58).

Published

1994-06-01

Issue

Section

Original Articles

How to Cite

Loffredo, L. de C. M., Souza, J. M. P. de, Yunes, J., Freitas, J. A. de S., & Spiri, W. C. (1994). Oral clefts: a case-control study . Revista De Saúde Pública, 28(3), 213-217. https://doi.org/10.1590/S0034-89101994000300009