Genomic Ancestry, socioeconomic status and vulnerability to HIV/AIDS in Bahia, Brazil
DOI:
https://doi.org/10.1590/S0104-12902010000600008Keywords:
AIDS, HIV, CCR5, CCR2, Genomic AncestryAbstract
The clinical course of HIV infection is determined by complex/ interactions between viral and host's characteristics./ Host variations, such as CCR5δ32 and CCR264I mutations, are important/ to vulnerability and progression of HIV/AIDS./ Currently, the number of cases among patients with lower educational level and lower social and economic status is/ increasing./ Aiming to/ estimate the ancestry and verify its association with income,/ education, vulnerability and progression of HIV/AIDS, 517 individuals infected with HIV-1 were studied (55.9% men and 43.3% women). The/ patients were/ classified according to/ genomic ancestry evaluated by 10 AIMs and by vulnerability and/ progression of HIV/AIDS through CCR5δ32 and CCR264I mutations./ The/ individuals infected with HIV-1 showed 47% of African contribution./ CCR5δ32 and CCR264I mutations were more frequent in white/ (3%) and black (18%) individuals, respectively, and these same mutations/ showed higher frequency in the typically progressive HIV-infected individuals (TP), when compared to the rapidly progressive (RP)./ There was no association between ancestry and/ vulnerability to HIV in the analysis of level of education./ The pauperization of the HIV-1 infection in this population was confirmed by/ the inverse relationship between income and African ancestry, because the lower/ the income, the greater the African ancestry./ The results suggest that there is an association between socioeconomic status and vulnerability to HIV/AIDS in the Afro-descendant population.Downloads
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Published
2010-12-01
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Section
nd431043982
How to Cite
Abe-Sandes, K., Bomfim, T. F., Machado, T. M. B., Abe-Sandes, C., Acosta, A. X., Alves, C. R. B., & Castro Filho, B. G. (2010). Genomic Ancestry, socioeconomic status and vulnerability to HIV/AIDS in Bahia, Brazil . Saúde E Sociedade, 19(supl.2), 75-84. https://doi.org/10.1590/S0104-12902010000600008