A structuralist analysis of Hill's theories: an elucidation of explanation in Biochemistry
DOI:
https://doi.org/10.1590/S1678-31662013000200005Keywords:
Explanation, Structuralism, Theory, Biochemistry, MechanismAbstract
Usually, scientists differentiate between explanatory and descriptive scientific theories. To be able to analyze this difference is necessary to provide a rigorous analysis of scientific theories - the structuralist point of view is a metatheoretic tool capable of offering the metatheoretic elements needed for this. The aim of the present work is to analyze Hill's theory (both as originally published and as presented in textbooks), a theory about the cooperative activity of the proteins, in order to elucidate the concept of explanation used in it.Downloads
References
Adair, G. S. The hemoglobin system vi. The oxygen dissociation curve of haemoglobin. Journal of Biological Chemistry. 63, p. 529-45, 1925.
Balzer, W.; Moulines, C. U. & Sneed, J. D. An architectonic for science. The structuralist program. Dordrecht: Reidel, 1987.
Balzer, W. & Moulines, C. U. (Ed.). Structuralist theory of science: focal issues, new results. Berlin/New York: Walter de Gruyter, 1996.
Bartelborth, T. Begründungsstrategien. Ein Weg durch die analytische Erkenntnistheorie, Berlin: Akademie Verlag, 1996a.
Bartelborth, T. Scientific Explanation. In: Balzer, W. & Moulines, C. U. (Ed.). Structuralist theory of science: focal issues, new results. Berlin/New York: Walter de Gruyter, 1996b. p. 23-43.
Bartelborth, T. Coherence and explanation. Erkenntnis, 50, p. 209-24, 1999.
Bartelborth, T. Explanatory unification. Synthese, 130, p. 91-107, 2002.
Bechtel, W. & Richardson, R. C. Discovering complexity: decomposition and localization as strategies in scientific research. Princeton: Princeton University Press, 1993.
Bindslev, N. Drug-acceptor interactions: modeling theoretical tools to test and evaluate experimental equilibrium effects. Järfälla: Co-Action Publishing, 2008.
Blanquart, C.; Yanes, C. G. & Issad, T. Monitoring the activation state of insulin/insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer. Molecular Pharmacology, 70, p. 1802-11, 2006.
Bublil, E. M. & Yarden, Y. The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr Opin. Cell Biology, 19, p. 124-34, 2007.
Craver, C. F. & Darden, L. Introduction. Studies in History and Philosophy of Biological and Biomedical Sciences, 36, p. 233-44, 2005.
Díez, J. A. Explicación, unificación y subsunción teórica. In: González, W. (Ed.). Pluralidad de la explicación científica. Barcelona: Ariel, 2002. p. 73-93.
Díez, J. A. & Lorenzano, P. (Ed.). Desarrollos actuales de la metateoría estructuralista: problemas y discusiones. Quilmes: Universidad Nacional de Quilmes/Universidad Autónoma de Zacatecas/Universidad Rovira i Virgili, 2002.
Díez, J. A. & Lorenzano, P. La concepción estructuralista en el contexto de la filosofía de la ciencia del siglo xx. In: Díez, J. A. & Lorenzano, P. (Ed.). Desarrollos actuales de la metateoría estructuralista: problemas y discusiones. Quilmes: Universidad Nacional de Quilmes/Universidad Autónoma de Zacatecas/Universidad Rovira i Virgili, 2002a. p. 13-78.
Ernst, G. & Niebergall, K.-G. (Ed.). Philosophie der Wissenschaft – Wissenschaft der Philosophie. Festschrift für C.Ulises Moulines zum 60. Geburstag. Paderborn: Mentis-Verlag, 2006.
Falguera, J. L.; Martínez, M .C. & Sagüillo, J. M. (Ed.). Current topics in logic and analytic philosophy/temas actuales de lógica y filosofía analítica, Santiago de Compostela: Universidade de Santiago de Compostela. 2007.
Forge, J. Reflections on structuralism and scientific explanation. Synthese, 130, p. 109-21, 2002.
González, W. (Ed.). Pluralidad de la explicación científica. Barcelona: Ariel, 2002.
Goutelle, S. et al. The Hill equation: a review of its capabilities in pharmacological modeling. Fundamental Clinical Pharmacology, 22, p. 633-48, 2008.
Hill, A. V. The possible effects of aggregation of the molecules of haemoglobin on its dissociation curve. Proceedings of the Physiological Society, 40, p. iv-vii, 1910.
Hill, A. V. Trails and trials in physiology. London: Edward Arnold, 1965.
Hempel, C. G. The theoretician’s dilemma. In: Feigl, H.; Scriven, M. & Maxwell, G. (Ed.). Concepts, theories, and mind-body problem. Minneapolis: University of Minnesota Press, 1958. p. 37-98.
Kuhn, T. S. The structure of scientific revolutions. 2 ed. Chicago: University of Chicago Press, 1970.
Lorenzano, C. Una reconstrucción estructural de la bioquímica. In: Díez, J. A. & Lorenzano, P. (Ed.). Desarrollos actuales de la metateoría estructuralista: problemas y discusiones. Quilmes: Universidad Nacional de Quilmes/Universidad Autónoma de Zacatecas/Universidad Rovira i Virgili, 2002. p. 209-30.
Lorenzano, C. La estructura ejemplar de la bioquímica. Revista de Filosofía, 32, 1, p. 7-31, 2001.
Lorenzano, P. Comentarios a “Explicación teórica y compromisos ontológicos: Un modelo estructuralista” de C. Ulises Moulines. Enrahonar, 37, p. 55-9, 2005.
Lorenzano, P. Fundamental laws and laws of biology. In: Ernst, G. & Niebergall, K.-G. (Ed.). Philosophie der Wissenschaft – Wissenschaft der Philosophie. Festschrift für C.Ulises Moulines zum 60. Geburstag. Paderborn: Mentis-Verlag, 2006. p. 129-55.
Lorenzano, P. Exemplars, models and laws in classical genetics. In: Falguera, J. L.; Martínez, M .C. & Sagüillo,
J. M. (Ed.). Current topics in logic and analytic philosophy/temas actuales de lógica y filosofía analítica, Santiago de Compostela: Universidade de Santiago de Compostela. 2007. p. 89-102.
Monod, J.; Wyman, J. & Changeux, J. P. On the nature of allosteric transitions: a plausible model. Journal of Molecular Biology, 12, p. 88-118, 1965.
Moulines, C. U. Explicación teórica y compromisos ontológicos. Enrahonar, 37, p. 45-54, 2005.
Muirhead, H. & Perutz, M. Structure of haemoglobin. A three-dimensional Fourier synthesis of reduced human haemoglobin at 55 a Resolution. Nature, 199, p. 633-9, 1963.
Perutz, M. X-ray analysis of hæmoglobin. Nature, 149, p. 491-4, 1942.
Perutz, M. Structure of haemoglobin. Brookhaven Symposium Biology, 13, p. 165-83, 1960.
Stoker, A. W. Protein tyrosine phosphatases and signalling. Journal of Endocrinology, 185, p. 19-33, 2005.
Voet, D. & Voet, J. Bioquímica. Buenos Aires: Panamericana, 2006.
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