Thrombosis and amputation in acute COVID-19: a case report
DOI:
https://doi.org/10.11606/issn.2317-0190.v31i2a214105Keywords:
Covid-19, Amputees, Thrombosis, RehabilitationAbstract
During the outbreak of COVID-19, it has been discovered that the infection was associated to increased risk of venous or arterial thromboembolic events and many other dysfunctions in various systems of human body. In relation to thrombosis, in molecular/cellular levels numerous signaling pathways due to dysregulated RAAS may contribute to the observed coagulopathy in COVID-19. On the other hand, excessive innate immune response to SARS-CoV2 for which there is no prior acquired immunity mediates various pathways that may lead to thrombosis. Case report: This case report analyzes those hematologic disfunctions in a patient affected for a post COVID-19 conditions associated to a long-term hospitalization resulting in a bunch of sequels. We emphasized the transfemoral amputation was due to proximal arterial thrombosis and the functional loss related to it. We aborted the whole rehabilitation plan and its implementation since the beginning of the process of dehospitalization. We describe the role of each professional of the multi-professional team, the pharmacologic and non-pharmacologic treatment, the assistive technologies applied, the other sequels related to post COVID-19 conditions and long-term hospitalization and their functional gains. We used the Functional Independence Measure (MIF) to do the follow up of the case, 84 to 96. As results of the therapeutic program, the patient could achieve a high grade of modified independence for activities of daily living (ADLS) and Instrumental activities of daily living. Conclusion: Thrombosis and amputations are complications in COVID-19 patients. The absence of a multidisciplinary program of rehabilitation will cause to the patient an increasing risk of development of psychologic affections and great impact of their social life.
Downloads
References
Etkin Y, Conway AM, Silpe J, Qato K, Carroccio A, Manvar-Singh P, et al. Acute Arterial Thromboembolism in Patients with COVID-19 in the New York City Area. Ann Vasc Surg. 2021;70:290-294. Doi: https://doi.org/10.1016/j.avsg.2020.08.085
Muñoz-Rivas N, Abad-Motos A, Mestre-Gómez B, Sierra-Hidalgo F, Cortina-Camarero C, Lorente-Ramos RM, et al. Systemic thrombosis in a large cohort of COVID-19 patients despite thromboprophylaxis: A retrospective study. Thromb Res. 2021;199:132-142. Doi: https://doi.org/10.1016/j.thromres.2020.12.024
Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191:9-14. Doi: https://doi.org/10.1016/j.thromres.2020.04.024
Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers DAMPJ, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145-147. Doi: https://doi.org/10.1016/j.thromres.2020.04.013
Thomas W, Varley J, Johnston A, Symington E, Robinson M, Sheares K, et al. Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom. Thromb Res. 2020;191:76-77. Doi: https://doi.org/10.1016/j.thromres.2020.04.028
Tan BK, Mainbourg S, Friggeri A, Bertoletti L, Douplat M, Dargaud Y, et al. Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis. Thorax. 2021;76(10):970-979. Doi: https://doi.org/10.1136/thoraxjnl-2020-215383
Candeloro M, Schulman S. Arterial Thrombotic Events in Hospitalized COVID-19 Patients: A Short Review and Meta-Analysis. Semin Thromb Hemost. 2023;49(1):47-54. Doi: https://doi.org/10.1055/s-0042-1749661
Mirelman A, Shema S, Maidan I, Hausdorff JM. Gait. Handb Clin Neurol. 2018;159:119-134. Doi: https://doi.org/10.1016/B978-0-444-63916-5.00007-0
Holtzer R, Schoen C, Demetriou E, Mahoney JR, Izzetoglu M, Wang C, et al. Stress and gender effects on prefrontal cortex oxygenation levels assessed during single and dual-task walking conditions. Eur J Neurosci. 2017;45(5):660-670. Doi: https://doi.org/10.1111/ejn.13518
Mandali A, Weidacker K, Kim SG, Voon V. The ease and sureness of a decision: evidence accumulation of conflict and uncertainty. Brain. 2019;142(5):1471-1482. Doi: https://doi.org/10.1093/brain/awz013
Pruziner AL, Shaw EP, Rietschel JC, Hendershot BD, Miller MW, Wolf EJ, et al. Biomechanical and neurocognitive performance outcomes of walking with transtibial limb loss while challenged by a concurrent task. Exp Brain Res. 2019;237(2):477-491. Doi: https://doi.org/10.1007/s00221-018-5419-8
Chen FT, Soya H, Yassa MA, Li RH, Chu CH, Chen AG, et al. Effects of exercise types on white matter microstructure in late midlife adults: Preliminary results from a diffusion tensor imaging study. Front Aging Neurosci. 2022;14:943992. Doi: https://doi.org/10.3389/fnagi.2022.943992
Ji Z, Feng T, Wang H. The Effects of 12-Week Physical Exercise Tapping High-level Cognitive Functions. Adv Cogn Psychol. 2020;16(1):59-66. Doi: https://doi.org/10.5709/acp-0284-5
Brugliera L, Spina A, Castellazzi P, Cimino P, Arcuri P, Deriu MG, et al. Rehabilitative of COVID-19 patients withacute lower extremity Ischemia and amputation. J Rehabil Med. 2020;52(9):jrm00094. Doi: https://doi.org/10.2340/16501977-2714
Wada Y, Hirano S, Kumagai A, Takeuchi K, Inagaki R, Hosokawa H, et al. Rehabilitation of a Patient with COVID-19 Who UnderwentRight Transfemoral Amputation Due to Acute Limb Ischemia: A Case Report. ProgRehabil Med. 2022;7:20220052. Doi: https://doi.org/10.2490/prm.20220052
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Acta Fisiátrica
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.