Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules

Authors

  • Vladi Olga Consiglieri University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Samanta Mourão University of Vale do Itajaí; Faculty of Pharmacy
  • Mauricio Sampaio University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Patricia Granizo University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Pedro Garcia University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Valeska Martinello University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Rodrigo Spricigo University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Humberto Gomes Ferraz University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department

DOI:

https://doi.org/10.1590/S1984-82502010000100013

Keywords:

Fluconazole^i1^sflowabil, Tablets^i1^sdissolut, Capsules^i1^sdissolut, Plasdone

Abstract

The aim of this work was to improve fluconazole flowability by wet granulation and to study the effect of granulation on drug dissolution from tablets and capsules. Fluconazole was submitted to a process of wet granulation in a high-speed granulator using Plasdone® K29/32 or K90. Flow properties of granules and dissolution profiles for tablets and capsules produced with them were determined. Fluconazole granules demonstrated better flowability, calculated by angle of repose and compressibility index data, compared with powder. Additionally, it was observed that the granulation process improved the dissolution efficiency (ED) of fluconazole from tablets and capsules, which could also suggest an increase in bioavailability. Higher dissolution efficiencies were achieved with Plasdone® K29/32.

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Published

2010-03-01

Issue

Vol. 46 No. 1 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

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How to Cite

Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(1), 115-120. https://doi.org/10.1590/S1984-82502010000100013