Instructions to Authors

Information specific to the submission process is avaliable at Submissions.

INSTRUCTIONS TO AUTHORS

According to the Journal’s policy, manuscripts will not be accepted for publication for the following reasons:

1. Out of scope
The work must be based on a thorough and extensive study, using established or well-described methods and including proper controls. Research must be hypothesis-driven and conclusions must be supported by the data presented.
Immediate rejection criteria:
a. Description of analytical methods with no relation to pharmaceutics, biopharmaceutics, or pharmaceutical biotechnology.
b. Mere description of compound synthesis, processes, validation, etc. without any pharmaceutical application.
c. Manuscripts describing plant extract activity that do not identify qualitative and quantitative chemical markers of the extract.
d. Inappropriate promotion of a trademark or a product.
e. Regulatory issues with no relation to pharmaceutics, biopharmaceutics, or pharmaceutical biotechnology.

2. Too preliminary
A paper must be based on a thorough and extensive study, using established or welldescribed methods and including proper controls. Research must be hypothesisdriven and conclusions must be supported by the data presented.
Immediate rejection criteria:
a. No proof of concept in either an in vivo or an in vitro evaluation.
b. No clear indication of the use of the product or formulation.
c. No clear description of the materials & methods used in the pharmaceutical field.
d. Use of inadequate or insufficient methods.
e. Inappropriate statistical analysis.
f. Lack of proper controls.
g. Lack of coherent discussion of the results.

3. Lack of novelty
The study described in the manuscript must represent a novel approach.
Immediate rejection criteria:
a. Repetition of previously published data, either partially or entirely.
b. Simple variation of parameters of a formulation, processes, synthesis, etc.
c. Modification of well-known delivery systems with no novelty and/or benefit.
d. Plagiarism (unacknowledged copying of other’s work) and self-plagiarism (reuse of parts of an author’s previously published work without proper citation).

In addition, will not be accepted for publication:
a. Studies on human subjects not approved by an accredited Ethics Committee or without written informed consent from the subject or legal guardian.
b. Studies on animals not approved by an accredited Ethics and Animal Care Committee.

Before preparing your manuscript for submission to the Brazilian Journal of Pharmaceutical Sciences, it is imperative that authors meticulously review and follow the guidelines outlined in the section "Preparation of the Manuscript". This introduction serves to emphasize critical aspects that need to be adhered to facilitate a smooth review and publication process. Ensuring compliance with these guidelines not only streamlines the editorial workflow but also enhances the scientific integrity and dissemination of your research. Here is a brief overview to guide your preparation and submission process:
1. **Language and Originality**: All manuscripts must be submitted in English, and the submission must be original work that has not been published elsewhere nor is it under consideration by another publication.
2. **Authorship Criteria**: Only individuals who have significantly contributed to the research and manuscript preparation should be listed as co-authors. Additionally, authors must participate in the discussion of results and approve the final version of the manuscript.
3. **Submission Requirements**: Alongside the manuscript, authors need to include a signed letter as part of the submission package. Authors are required to perform a plagiarism check using any freely available online software and must submit a certificate along with their manuscript asserting that the text does not contain plagiarism. This step places the initial responsibility on the authors to ensure their work is free of plagiarism before formal review. Failure to include this form will prevent the manuscript from proceeding to the review stage.
4. **Peer Review Process**: Manuscripts that meet the submission guidelines will be subject to a peer review by at least two independent referees. The final decision on the manuscript will be made by the Editor-in-Chief based on the referees' recommendations.
5. **Revision Process**: If revisions are necessary, authors are expected to resubmit the revised manuscript within 60 calendar days, incorporating all suggestions and providing a detailed response to reviewer comments.

TYPES OF DOCUMENT ACCEPTED
Brazilian Journal of Pharmaceutical Sciences will publish the following type of
manuscript categories:

Full-Length Original Paper
This is a detailed study reporting original research, including comprehensive data and results.
Each manuscript should clearly state its objective or hypothesis; the experimental design and methods used; the essential features of any interventions; the main outcome measures; the main results of the study; and a discussion placing the results in the context of published literature.
The manuscript should contain:
a. abstract of no more than 200 words;
b. no more than 6 keywords;
c. a running title to be used as a page heading, which should not exceed 60 characters;
d. manuscript's main body divided into separate sections (Introduction, Material and Methods, Results and Discussion)
e. no more than 40 references;
f. Supplementary data - can be submitted as a Supplementary information session.

Short Communication
Short communication is a limited report of significant and original experimental and/or theoretical results that fit within the scope of the Journal. It must be of sufficient importance and general interest to justify publication.
The manuscript should contain:
a. abstract of no more than 200 words;
b. no more than 6 keywords;
c. a running title to be used as a page heading, which should not exceed 60 characters;
d. manuscript's main body - divided into separate sections (Introduction, Material and Methods, Results and Discussion), without a separate section for conclusions. Preferably manuscripts should not exceed 2,000 words of text;
e. no more than 20 references;
f. no more than three illustrations (figures and/or tables).

Review Article
A review article should provide a synthetic and critical analysis of a relevant area and should not be merely a chronological description of the literature. A review article by investigators who have made substantial contributions to a specific area of Pharmaceutical Sciences will be published by invitation by the Editors. However, a letter of intention altogether with an outline of a review article may be submitted to the Editors without prior consultation. If it is judged appropriate for the Journal, the author(s) will be invited to prepare the article for peer review.
The manuscript should contain:
a. abstract of no more than 250 words;
b. no more than 6 keywords;
c. a running title to be used as a page heading, which should not exceed 60 characters manuscript main body divided into sections with appropriate titles and subtitles;
d. no more than 120 references.

Mini review Article
A mini review is focused on a restricted part of a subject normally covered in a review article. The structure of the mini review follows the same rules as the review.

Concepts and Comments
The Concepts and Comments section provides a platform for readers to present
ideas, theories and views. The manuscript should contain:
a. abstract of no more than 250 words;
b. no more than 6 keywords;
c. a running title to be used as a page heading, which should not exceed 60 characters manuscript main body divided into sections with appropriate titles and subtitles;
d. no more than 40 references.

PREPARING YOUR MANUSCRIPT
Cover Letter
It is important that you include a cover letter with your manuscript. Take time to consider why this manuscript is suitable for publication in the Brazilian Journal of Pharmaceutical Sciences, why will your paper inspire other members of the field, and how will it drive research forward. Please explain these points in your cover letter.
The submission letter must also include the following information:
a. Title of article;
b. Name, filiation, e-mail and ORCID number of all authors;
c. Information of Corresponding Author: name and e-mail (full address and telephone number are optional information);
d. Disclosure of the use of AI;
e. Information of preprint: title, authors, repository name, publication date and DOI;
f. The submission letter must be signed by the corresponding author.

Authorship requirements
Only people who directly contributed to the intellectual content of the paper should be listed as authors. Manuscripts must be submitted electronically only. Confirmation of submission will be sent by email to all authors, for their agreement.

Authors should meet all following criteria, thereby taking public responsibility for the content of the paper:
a. Conceived, planned, and carried out the experiments presented in the manuscript or interpreted the data, or both.
b. Wrote the paper and/or reviewed successive versions.
c. Approved the final version.
d. Holding positions of administrative leadership, contributing to patients, and collecting and assembling data, however important to the research, are not by themselves criteria for authorship. Any person who has made a substantial, direct contribution to the work but cannot be considered an author should be cited in the Acknowledgment section, with permission, and include a description of his/her specific contribution to the research.

The Brazilian Journal of Pharmaceutical Sciences adopts the CRediT (Contributor Roles Taxonomy) taxonomy to accurately identify the contributions of each author in publications. This helps us to assign proper credit to each of the authors with transparency. For more information about the CRediT system, visit the official website: https://credit.niso.org/.
Before the references, a topic should be included indicating the contribution of each author to the research.

Article Submission Format
a. Manuscripts can only be accepted as Microsoft Word files created with MS Word (“doc”, “docx” or “RTF” document).
b. Manuscripts should be sent in 30-36 lines per page, 1,5 spaced, numbered in the upper right-hand corner starting with the title page as page 1.
c. Report all measurements in Système International, SI (http://physics.nist.gov/cuu/Units) and standard units where applicable.
d. Names of plants, animals and chemicals should be according to international rules available.
e. Names of drugs can follow the international rules (INN) or current Brazilian rules (DCB). Trademarks may be mentioned only once in the text (between parenthesis and initial in capital letter).
f. Do not use abbreviations in the title and limit their use in the abstract and main text.
g. The length of the manuscript and the number of tables and figures must be kept to a minimum.
h. Ensure that all references are cited in the text.
i. Generic names must be used for all drugs. Instruments may be referred to by proprietary name; the name and country of the manufacturer should be given in parenthesis.

ORGANIZATION OF THE MANUSCRIPT
Continuous page numbers are required for all pages including figures. There are no specific length restrictions for the overall manuscript or individual sections. However, we request authors to present and discuss their findings concisely. We recognize that some articles will not be best presented in the suggested research article format. If you have a manuscript that would benefit from a different format, please contact the editors for further discussion.
Preferably, manuscripts should be organized into the following sections:

TITLE PAGE
Title
The title should be as short and informative as possible, should not contain nonstandard acronyms or abbreviations, and should not exceed two printed lines. The title should be centered and written in bold as the example below:
FREEZE-DRYING OF AMPICILLIN SOLID LIPID NANOPARTICLES USING MANNITOL AS CRYOPROTECTANT

Running title
This short title, to be used as a page heading, should not exceed 60 characters.

Authors and Affiliations
Full name (matched with superscript numbers identifying affiliation) must be written in bold and centered. Institution(s) (Department, Faculty/School, University, City, State, Country) of each author (in English) must be centered and written in italic.

Example:
Hongmei Xia¹*, Yongfeng Cheng², Yinxiang Xu³, Zhiqing Cheng¹

¹College of Pharmacy, Anhui University of Chinese Medicine, Hefei, People’s Republic of China, ²School of Life Science, University of Science and Technology of China, Hefei, People’s Republic of China, ³Zhaoke (Hefei) Pharmaceutical Co. Ltd., Hefei, People’s Republic of China

Corresponding author
One of the authors should be designated as the corresponding author. It is the corresponding author ́s responsibility to ensure that the author list is accurate and complete. If the article has been submitted on behalf of a consortium, all consortium members and affiliations should be listed in the Acknowledgments section. Provide the name, full address, e-mail address and ORCID number of the author to whom correspondence should be sent, identified with an asterisk.

Abstract
Since abstracts are published separately by Information Services, they should contain sufficient hard data to be appreciated by the reader. The abstract should not exceed 200 words (250 for reviews) and should be prepared in a single paragraph without topic divisions and margins. The abstract should briefly and clearly present the objective, experimental approach, new results as quantitative data if possible, and conclusions. It should mention the techniques used without going into methodological detail and mention the most important results. Abbreviations should be kept to a minimum and should be defined in both the Abstract and text. Please do not include any reference citations in the abstract. If the use of a reference is unavoidable, the full citation should be given within the abstract.

Keywords
A list of keywords or indexing terms (no more than 6) should be included avoiding generic terms. Keywords must be separated by dots with only the first letter of the first word in upper case.
Example: Apoptosis pharmacokinetics. Toxicology.

INTRODUCTION
The Introduction should put the focus of the manuscript into a broader context and reflects the present state-of-art of the subject. This should state briefly and clearly the objectives of the investigation with reference to previous works. The introduction should justify the hypothesis of the study. An extensive review of the literature should be avoided and when possible, replaced by recent reviews of the subject.

MATERIAL AND METHODS
These should be described in sufficient detail that the work can be reproduced. Well-established procedures and techniques require only citation of the original source, except when they are substantially modified. Reports of experimental studies on humans and animals must certify (including the number of protocols) that the research received prior approval by the appropriate institutional review Ethics Committee.

RESULTS
Results must be presented clearly and concisely and in a logical order. This section should provide the results of all the experiments required to support the conclusions of the paper. When possible, use figures or tables to present data rather than text. Large datasets, including raw data, should be submitted as supplementary files; these are published online and linked to the article.

DISCUSSION
Discussion should interpret the results and assess their significance in relation to existing knowledge. Speculation not warranted by actual data should be avoided.
The Discussion should spell out the major conclusions and interpretations of the work including some explanation of the significance of these conclusions.

ACKNOWLEDGMENTS
When appropriate, briefly acknowledge technical assistance, advice, and contributions from colleagues. People who contributed to the work but do not fit the criteria for authors should be listed in the Acknowledgments section, along with their contributions. Donations of animals, cells, or reagents should also be acknowledged. Authors must ensure that anyone named in the Acknowledgments agrees to being so named. Financial support for the research and fellowships should be acknowledged in this section (agency and grant number).

FIGURES
Figures must be submitted in high-resolution (at least 300 dpi). They must be uploaded separately from the manuscript file. The following file formats are accepted: TIFF or JPEG.

Preparing figure files for submission
The use of figures is mandatory for original articles since it increases the clarity of data. The use of color figures is free of charge. The following guidelines must be observed when preparing figures. Failure to do so is likely to delay the acceptance and publication of the article.

a. Each figure of a manuscript should be submitted as a single file.
b. Individual figure files should not exceed 5 MB. If a suitable format is chosen, this file size is adequate for extremely high-quality figures. An enlarged version of the figure and its full legend will often be viewed in a separate window online, and it should be possible for a reader to understand the figure without moving back and forth between this window and the relevant parts of the text.
c. Figures should be numbered in the order they are first mentioned in the text and uploaded in this order. All figures must be cited in the text.
d. Figure captions, titles and legends should be provided in the main manuscript file, inside the “List of Figures” topic, and in the submission system. The figure file should be limited to the illustration alone to ensure better readability.
e. The aim of the figure legend is to describe the key messages of the figure, but the figure should also be discussed in the text.
f. The legend itself should be succinct, while still explaining all symbols and abbreviations. Avoid lengthy descriptions of methods. Statistical information should be given as well as the statistical tests used.
g. Arrows or letters used in the figure to identify important structures should be explained in the legend.
h. Figures with multiple panels should present capital letters A, B, C, etc. to identify the panels.
i. Each figure should be closely cropped to minimize the amount of white space surrounding the illustration. Cropping figures improves accuracy when placing the figure in combination with other elements when the accepted manuscript is prepared for publication.

Please note that it is the authors’ responsibility to obtain permission from the copyright holder to reproduce figures (or tables) previously published elsewhere, taking in consideration it will be published as open access. Permission should be indicated in the figure legend, and the original source included in the reference list.

TABLES
a. Must be submitted in Word (.doc) or Excel (.xls), not as an image.
b. Must be numbered consecutively with Roman numerals in the text.
c. Must have a concise and descriptive title. All explanatory information should
be given in a footnote below the table. Footnotes should be used to explain abbreviations and provide statistical information, including statistical tests used.
d. All abbreviations must be defined in the footnote, even if they are explained in the text.
e. Tables must be understandable without referring to the text.
f. Tables occupying more than one printed page should be avoided, if possible.
g. Vertical and diagonal lines should not be used in tables; instead, indentation and vertical or horizontal space should be used to group data.

CITATIONS
Citations should be prepared according to Vancouver's standard reference style (https://library.viu.ca/citing/vancouver). They consist of numbers formatted in superscript and placed after the end of the sentence. If the citation includes more than one reference, separate the numbers with a comma or include a range by separating the first and last numbers with a hyphen.
Examples:
Reference one¹. References two and thirteen²,¹³. References one through three¹-³.

REFERENCES
References should be formatted in the Vancouver style (see the examples below). They should be numbered according to the order in which they appear in the text. The accuracy and completeness of reference data is the responsibility of the authors.
Only published references or accepted in the publication phase should be included in the reference list. Meeting abstracts, conference talks, or papers that have been submitted but not yet accepted should not be cited. Limited citation of unpublished work should be included in the body of the text only. All personal communications should be supported by a letter from the relevant authors.

Published Papers: All authors should be included in reference lists. Authors (Surname and first name’s initial). Title (Only the first letter in upper case). Journal abbreviation with dot only on the last word. Year;Volume(issue number):first page-last page.
Ali A, Iqbal F, Taj A, Iqbal Z, Amin MJ, Iqbal QZ. Prevalence of microvascular complications in newly diagnosed patients with Type 2 diabetes. Pak J Med Sci. 2013;29(4):899-902.
Calvo A, Gimenez MJ. Ex Vivo Serum Activity (Killing Rates) After Gemifloxacin 320 mg Versus Trovafloxacin 200 mg Single Doses Against CiprofloxacinSusceptible and -Resistant Streptococcus pneumonia. Int J Antimicr Ag. 2007;20:144-6.

Article accepted for publication but not yet published: Authors. Title. Journal (abbreviation in normal font), Year of expected publication (in press) at the end of the citation.
Janiszewski M, Lopes LR, Carmo AO, Pedro MA, Brandes RP, Santos CXC, Laurindo FR. Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells. J Biol Chem. 2005 (in press).

Internet Communication: Ensure that URLs are active and available. Provide
DOI, if available.
Brasil. Ministério da Saúde, Secretaria de Vigilância em Saúde. Leishmaniose visceral grave: normas e condutas [Internet]. Brasília (DF): Ministério da Saúde, 2006. [citado 2008 Jan 7]. 60 p. (Série A. Normas e Manuais Técnicos). Disponível em: http://dtr2001.saude.gov.br/editora/produtos/livros/pdf/06_0072_M.pdf
CAPES Statistics. [cited 2006 Mar 16]. Available from: http://www.capes.gov.br/capes/portal.
Developmental toxicology. [cited 2015 Apr 10]. Available from: http://www.devtox.org/nomenclature/organ.php.

Whole Book: Authors. Book title. Edition. City: Publisher; Year. page.
Hewitt W. Microbiological assay for pharmaceutical analysis: a rational approach. Boca Raton: CRC Press; 2003.
Jenkins PF. Making sense of the chest x-ray: a hands-on guide. New York: Oxford University Press; 2005. 194 p.

Book Chapter: Authors. Chapter Title. Editors. In: Editors Book. Book title. Edition. City, Publisher; Year. Pages of citation.
Rojko JL, Hardy WD Jr. Feline leukemia virus and other retroviruses. In: Sherding RG, editor. The cat: diseases and clinical management. New York: Churchill Livingstone; 1989. p. 229-332.

Laws:
Agência Nacional de Vigilância Sanitária (Brasil). Resolução no. 259, de 20 de setembro de 2002. Regulamento Técnico para Rotulagem de Alimentos Embalados. Diário Oficial da União 23 set 2002; Seção 1.

Conference or Symposium Proceedings: Cite papers only from published
proceedings.
Hejzlar RM, Diogo PA. The use of water quality modelling for optimizing operation of a drinking water reservoir. In: Proceedings of the International Conference Fluid Mechanics and Hydrology. 1999 Jun 23-26; Prague. Prague: Institute of Hydrodynamics AS CR; 1999. p 475-482. Proceedings of the 10th annual meeting of the Canadian Society for Pharmaceutical Sciences. J Pharm Pharm Sci. 2007 Dec 3;10(4):1s-186s.

Report
Page E, Harmey JM. Health hazard evaluation report. Cincinnati (OH): National Institute for Occupational Safety and Health (US); 2001 Feb. 24p. Report Nº.: HETA2000-0139-2824.

Audiovisual Material
Physician’s Desk Reference (PDR). Release 2003.1AX. [CD- ROM]. Montvale: Thomson PDR; 2003.

Computer Program
Dean AG, Dean JA, Coulombier D, Brendel KA, Smith DC, Burton AH, et al. Epi info, version 6.04: a word processing database and statistics program for public health on IBM- compatible microcomputers. [Computer program]. Atlanta: Centers of Disease Control and Prevention;1998.
World Health Organization. WHO. Working to overcome the global impact of neglected tropical diseases, First WHO report on neglected tropical diseases. Geneva, Switzerland: WHO Press; 2010.

Patent
Larsen CE, Trip R, Johnson CR. Methods for procedures related to the electrophysiology of the heart. Patent No.5.529.067. Novoste Corporation;1995.

Thesis and Dissertations
Joselevitch C. Visão no ultravioleta em Carassius auratus (Ostariophysi, Cypriformes, Cyprinidae): estudo eletrofisiológico do sistema cone - células horizontais. [dissertação]. São Paulo: Instituto de Psicologia, USP; 1999. Hernandez CD. Pharmacogenomic analysis in patients with familial hypercholesterolemia [master´s thesis]. São Paulo, Faculdade de Ciências Farmacêuticas, USP; 2021.

Unpublished results and Personal communication: Reference should appear in the text with the individual name(s) and initials and not in the reference list.
(Santos CS, da-Silva GB, Martins LT, unpublished results).
It is assumed that the author has obtained permission from the source when personal communication is cited.

Complementary Information
This journal follows the principles of transparency and good practices in academic publications established by COPE, available in: https://publicationethics.org