Comparative study of analytical methods by direct and first-derivative UV spectrophotometry for evaluation of losartan potassium in capsules

Authors

  • Rudy Bonfilio Universidade Estadual Paulista Júlio de Mesquita Filho; Faculdade de Ciências Farmacêuticas; Departamento de Fármacos e Medicamentos
  • Lívia Botacini Favoretto Universidade Federal de Alfenas; Centro de Equivalência Farmacêutica; Departamento de Farmácia
  • Gislaine Ribeiro Pereira Universidade Federal de Alfenas; Centro de Equivalência Farmacêutica; Departamento de Farmácia
  • Roberta de Cássia Pimentel Azevedo Universidade Federal de Alfenas; Centro de Equivalência Farmacêutica; Departamento de Farmácia
  • Magali Benjamim de Araújo Universidade Federal de Alfenas; Centro de Equivalência Farmacêutica; Departamento de Farmácia

DOI:

https://doi.org/10.1590/S1984-82502010000100017

Keywords:

Losartan potassium, Direct UV spectrophotometry, First-derivative UV spectrophotometry

Abstract

Losartan potassium is an antihypertensive non-peptide agent, which exerts its action by specific blockade of angiotensin II receptors. The aim of the present study was the validation and application of analytical methods for the quality control of losartan potassium 50 mg in pharmaceutical capsules, using direct and first-derivative UV spectrophotometry. Based on losartan potassium spectrophotometric characteristics, a signal at 205 nm of the zero-order spectrum and a signal at 234 nm of the first-derivative spectrum, were found adequate for quantification. The results were used to compare these instrumental techniques. The linearity between the signals and concentrations of losartan potassium in the ranges of 3.0-7.0 mg L-1 and 6.0-14.0 mg L-1 for direct and first-derivative spectrophotometry in aqueous solutions, respectively, presented a correlation coefficient (r) of 0.9999 in both cases. The methods were applied for losartan potassium in capsule dosage obtained from local pharmacies, and were shown to be efficient, easy to apply and low cost. These methods do not use polluting reagents and require relatively inexpensive equipment.

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Published

2010-03-01

Issue

Section

Original Papers

How to Cite

Comparative study of analytical methods by direct and first-derivative UV spectrophotometry for evaluation of losartan potassium in capsules . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(1), 147-155. https://doi.org/10.1590/S1984-82502010000100017