Preliminary prospection of phytotherapic compounds from the essential oils from barks and leaves of Umburana (Commiphora Leptophloeos)

Authors

  • Keyla Bessa Pinto Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brasil
  • Pedro Henrique Batista Santos Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brasil
  • Laiza Canielas Krause Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brasil; Instituto de Tecnologia e Pesquisa, Aracaju, SE, Brasil
  • Elina Bastos Caramão Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brasil; Instituto de Tecnologia e Pesquisa, Aracaju, SE, Brasil; INCT-EA, Salvador, BA, Brasil
  • Thiago Rodrigues Bjerk Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brasil https://orcid.org/0000-0003-0067-6804

DOI:

https://doi.org/10.1590/s2175-97902022e21609

Keywords:

Commiphora leptophloeos, Medicinal plant, Gas chromatography, Essential oil

Abstract

The potential of the biome caatinga (exclusive from northeastern Brazil) has been evaluated in recent research for application in the pharmaceutical industry. Among the species of medicinal plants from caatinga, one can highlight the Commiphora leptophloeos (umburana), which has been used as infusions and syrups by the regional population for inflammatory and infectious diseases. Essential oils from umburana leaves and barks were obtained in a Clevenger apparatus and analyzed by gas chromatography/mass spectrometry, and total phenolic and flavonoids were determined by spectrophotometric analysis. It was observed that a large part of the major compounds present in the essential oil is described as having antitumor activity, enabling research in investigational oncology with umburana (C. leptophloeos). In addition, some little explored components have been identified, such as cadinene, alpha-selinene, and elemenone. Despite being easily found in several plants, there are no clinical trials involving their biological activity in a well-defined isolated form, which could make exploring new studies possible. Furthermore, the presence of phenolic compounds and flavonoids allows future studies about the potential antimicrobial and antioxidant activity.

Downloads

Download data is not yet available.

References

Ahamad SR, Al-Ghadeer AR, Ali R, Qamar W, Aljarboa S. Analysis of inorganic and organic constituents of myrrh resin by GC-MS and ICP-MS: An emphasis on medicinal assets. Saudi Pharm J. 2017;25(5):788-794.

Badshah H, Ali T, Rehman SU, Amin FU, Ullah F, Kim TH, et al. Protective effect of lupeol against lipopolysaccharide- induced neuroinflammation via the p38/c-Jun N-terminal kinase pathway in the adult mouse Brain. J Neuroimmune Pharmacol. 2016;11(1):48-60.

Barbosa AM, Santos KS, Borges GR, Munizc AVCS, Mendonça FMR, Pinheiro MS, et al. Separation of antibacterial biocompounds from Hancornia speciosa leaves by a sequential process of pressurized liquid extraction. Sep Purif Technol. 2019;222:390-395.

Beserra FP, Xue M, Maia GLA, Rozza AL, Pellizzon CH, Jackson CJ. Lupeol, a Pentacyclic triterpene, promotes migration, wound closure, and contractile effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways. Molecules. 2018;23(11):2819.

Da Silva RCS, Milet-Pinheiro P, Da Silva PCB, Da Silva AG, Da Silva MV, Navarro DMDAF, et al. (E)-Caryophyllene and α-Humulene: Aedes aegypti oviposition deterrents elucidated by gas chromatography-electrophysiological assay of Commiphora leptophloeos leaf oil. Plos One. 2015;10(12):e0144586.

Djeridane A, Yousfi M, Nadjemi B, Boutassouna D, Stocker P, Vidal N. Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food Chem. 2006;97:654-660.

Di Giacomo S, Abete L, Cocchiola RM, Mazzanti G, Eufemi M, Di Sotto A. Caryophyllane sesquiterpenes inhibit DNA- damage by tobacco smoke in bacterial and mammalian cells. Food Chem. Toxicol. 2018;111:393-404.

Di Giacomo S, Di Sotto A, El-Readi M, Mazzanti G, Wink M. Chemosensitizing Properties of β-Caryophyllene and β-Caryophyllene Oxide in Combination with Doxorubicin in Human Cancer Cells. Anticancer Res. 2017;37(3):1191-1196.

Dong L, Luo Q, Cheng LZ, Yan YM, Cheng YX, Wang SM. New terpenoids from Resina Commiphora. Fitoterapia. 2017;117:147-153.

Dutra RC, Campos MM, Santos ARS, Calixto JB. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives. Pharmacol Res. 2016;112:4-29.

Elagbar ZA, Naik RR, Shakya AK, Bardaweel SK. Fatty Acids Analysis, Antioxidant and Biological Activity of Fixed Oil of Annona muricata L. Seeds. J Chem. 2016;1-6.

Endrini S, Rahmat A, Ismail P, Taufiq -Yap YH. Cytotoxic effect of γ-sitosterol from Kejibeling (Strobilanthes crispus) and its mechanism of action towards c-myc gene expression and apoptotic pathway. Med J Indones. 2014;23:203-208.

Fang Y, Kang Y, Zou H, Cheng X, Xie T, Shi L, et al. β-elemene attenuates macrophage activation and proinflammatory factor production via crosstalk with Wnt/β-catenin signaling pathway. Fitoterapia . 2018;124:92-102.

Fidyt K, Fiedorowicz A, Strządała L, Szumny A. β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties. Cancer Med. 2016;5(10):3007-3017.

Gandhi GR, Neta MTSL, Sathiyabama RG, Quintans JSS, Silva AMO, Araújo AAS, et al. Flavonoids as Th1/Th2 cytokines immunomodulators: A systematic review of studies on animal models. Phytomedicine. 2018;44:74-84.

Govindarajan M, Rajeswary M, Senthilmurugan S, Vijayan P, Alharbi NS, Kadaikunnan S, et al. Curzerene, trans-β-elemenone, and γ-elemene as effective larvicides against Anopheles subpictus, Aedes albopictus, and Culex tritaeniorhynchus: toxicity on non-target aquatic predators. Environ Sci Pollut Res. 2018;25(11):10272-10282.

Hammad FT, Ojha S, Azimullah S, Lubbad L. Does β-caryophyllene protect against renal dysfunction following ischemia-reperfusion injury in the rat? Int J Physiol Pathophysiol Pharmacol. 2018;10(6):63-171.

Hou HS, Bonku EM, Zhai R, Zeng R, Hou YL,Yang ZH, et al. Extraction of essential oil from Citrus reticulate Blanco peel and its antibacterial activity against Cutibacterium acnes (formerly Propionibacterium acnes). Heliyon. 2019,5:1-6.

Hsu MJ, Peng SF, Chuen FS, Tsia CH, Tsai FJ, Huang CY, et al. Lupeol suppresses migration and invasion via p38/MAPK and Pl3K/Akt signaling pathways in human osteosarcoma U-2 OS cells. Biosci Biotechnol Biochem. 2019;83(9):1-11.

Jarger BN, Parylak SL, Gage FH. Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation. Mol Asp Med. 2018;61:50-62.

Kim WK, Song SY, Oh WK, Kaewsuwan S, Tran TL, Kim WS, et al. Wound-healing effect of ginsenoside Rd from leaves of Panax ginseng via cyclic AMP-dependent protein kinase pathway. Eur J Pharmacol. 2013;702(1-3):285-293.

Li H, Ge Y, Zhou Y, Zhang X, Zhang J, Fu Q. Evaluation of the chemical composition, antioxidant and anti-inflammatory activities of distillate and residue fractions of sweet basil essential oil. J Food Sci Technol. 2017;54(7):1882-1890.

Mhalla D, Bouassida KZ, Chawech R, Bouaziz A, Makni S, Jlaiel L, et al. Antioxidant, hepatoprotective and antidepressant effects of Rumex tingitanus extracts and identification of a new bioactive compound. Biomed Res Int. 2018;59:1-10.

Oteiza PI, Fraga CG, Mills DA, Taft DH. Flavonoids and the gastrointestinal tract: local and systemic effects. Mol Asp Med . 2018;61:41-49.

Pereira JJS, Pereira APC, Jandú JJB, Da Paz JÁ, Crovella S, Correia MTS, et al. Commiphora leptophloeos phytochemical and antimicrobial characterization. Front Microbiol. 2017;8: 52-62.

Rhourrhi-Frih B, West C, Pasquier L, Chaimbault P, Lafosse M. Classification of natural resins by liquid chromatography- mass spectrometry and gas chromatography-mass spectrometry using chemometric analysis. J Chromatogr A. 2012;1256:177-190.

Rufino MSM, Fernades FAN, Alves RE, Brito ES. Free radical-scavenging behaviour of some north-east Brazilian fruits in a DPPHradical dot system. Food Chem . 2009;114:693-695.

Santos ATB, Araújo TFS, Silva LCN, Silva CB, Oliveira AFM, Araújo JM, et al. Organic extracts from Indigofera suffruticosa leaves have antimicrobial and synergic actions with erythromycin against Staphylococcus aureus Front Microbiol . 2015;6:1-7.

Silva APSA, Silva LCN, Fonseca CSM, Araújo JM, Correia MTS, Cavalcanti MS, et al. Antimicrobial activity and phytochemical analysis of organic extracts from Cleome spinosa Jaqc. Front Microbiol . 2016;7:1-10.

Silva RCS, Ferreira RLC, Da Silva JAA, Meunier IMJ, Berger R. Phytosociological aspects and growth of Commiphora leptophloeos in Brazilian Semiarid. Braz J Forest Res. 2017;37:11-18.

Singh B, Singh JP, Kaur A, Singh N. Phenolic composition and antioxidant potential of grain legume seeds: a review. Food Res Int. 2017;101:1-6.

Sirikhansaeng P, Tanee T, Sudmoon R, Chaveerach A. Major phytochemical as γ-sitosterol disclosing and toxicity testing in lagerstroemia species. Evid Based Complement Alternat Med. 2017;2017:1-10.

Styrczewska M, Kostyn A, Kulma A, Majkowska-Skrobek G, Augustyniak D, Prescha A, et al. Flax fiber hydrophobic extract inhibits human skin cells inflammation and causes remodeling of extracellular matrix and wound closure activation. BioMed Res Int. 2015;2015:862391.

Suttiarporn P, Chumpolsri W, Mahatheeranont S, Luangkamin S, Teepsawang S, Leardkamolkarn V. Structures of Phytosterols and Triterpenoids with Potential Anti-Cancer Activity in Bran of Black Non-Glutinous Rice. Nutrients. 2015;7(3):1672-1687.

Talhaoui N, Veza T, Caravaca AMG, Fernández-Gutiérrez A, Galvez J, Carretero AS. Phenolic compounds and in vitro immunomodulatory properties of three Andalusian olive leaf extracts. J Funct Foods. 2016;22:270-277.

Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and Extraction: a review. Int Pharm Sci. 2011;1:98-106.

Trentin DS, Giordani RB, Zimmer KR, Da Silva AG, Da Silva MV, Correia MTS, et al. Potential of medicinal plants from the Brazilian semi-arid region (Caatinga) against Staphylococcus epidermidis planktonic and biofilm lifestyles. J Ethnopharmacol. 2011;137(1):327-335.

Viveros-Paredes JM, González-Castañeda RE, Gertsch J, Chaparro-Huerta V, López-Roa RI, Vázquez-Valls E, et al. Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson’s Disease Induced by MPTP. Pharmaceuticals. 2017;10(3):60.

Wang Y, Hong D, Qian Y, Tu X, Wang K, Yang X, et al. Lupeol inhibits growth and migration in two human colorectal cancer cell lines by suppression of Wnt-β-catenin pathway. Onco Targets Ther. 2018;11:9787-7999.

Yeo SK, Ali AY, Hayward OA, Turnham D, Jackson N, Bowen ID, et al. β-bisabolene, a sesquiterpene from the essential oil extract of opoponax (Commiphora guidottii), exhibits cytotoxicity in breast cancer cell lines. Phytother Res. 2016;30(3):418-425.

Yin JL, Wong WS. Production of santalenes and bergamotene in Nicotiana tabacum plants. Plos One . 2019;14(1):1-16.

Yoshida Y, Niki E. Antioxidant effects of phytosterol and its components. J Nutr Sci Vitaminol. 2003;49(4):277-280.

Yousefian M, Shakour N, Hosseinzadeh H, Hayes AW, Hadizadeh F, Karimi G. The natural phenolic compounds as modulators of NADPH oxidases in hypertension. Phytomedicine . 2018;55:200-2013.

Zhu S, Qin DWS, Yang C, Li G, Cheng Y. Commiphora lactam A, a cytotoxic sesquiterpenoidal lactam from resina Commiphora. Fitoterapia . 2019;134:382-388.

Downloads

Published

2023-02-15

Issue

Section

Original Article

How to Cite

Preliminary prospection of phytotherapic compounds from the essential oils from barks and leaves of Umburana (Commiphora Leptophloeos). (2023). Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e21609