Development of a multiparticulate system containing enteric-release mini-tablets of omeprazole
DOI:
https://doi.org/10.1590/S1984-82502014000300008Abstract
The main aim of this study was to develop a multiparticulate system containing mini-tablets of omeprazole formulated with an enteric polymer with pH-dependent solubility. Pre-formulation studies showed good flow and compaction capacity, leading to the production ofhigh quality mini-tablets. The mini-tablets were coated in a fluidized bed with hydroxypropylmethylcellulose /Eudragit(r) L30D55 and packed into hard gelatin capsules. The dissolution profile showed gastro-resistance and zero-order kinetics. The dissolution profile for the formulation containing lactose as the diluent and coated with 12% (tablet weight gain) of polymer was similar to that ofthe reference drug.Downloads
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Published
2014-09-01
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How to Cite
Development of a multiparticulate system containing enteric-release mini-tablets of omeprazole . (2014). Brazilian Journal of Pharmaceutical Sciences, 50(3), 505-511. https://doi.org/10.1590/S1984-82502014000300008