Co-infection of Cytauxzoon felis, Mycoplasma haemofelis, and the feline immunodeficiency virus in a domestic cat in Uberlândia, Minas Gerais, Brazil
DOI:
https://doi.org/10.11606/issn.1678-4456.bjvras.2023.210131Keywords:
Cytauxzoonosis, Feline retroviruses, FIV, Hemoplasmosis, MycoplasmosisAbstract
Cytauxzoon felis is a hemoparasite capable of infecting domestic and wild cats. Studies suggest that wild cats are the main reservoirs of the protozoan, and transmission occurs through the bite of an infected tick. Hemotropic mycoplasmas are Gram-negative bacteria responsible for severe hemolytic anemia. The feline immunodeficiency virus (FIV) is a retrovirus capable of generating immunosuppression in the host and persistent infection. The present work describes a case of co infection of Cytauxzoon felis, Mycoplasma haemofelis, and feline immunodeficiency virus (FIV) in a cat. A feline from the rural area was admitted to the Veterinary Hospital of Uberlândia - MG of the Federal University of Uberlândia. Fresh whole blood samples were collected for blood count, enzymatic analysis, DNA extraction, real-time PCR for the detection of Cytauxzoon felis and Mycoplasma haemofelis, and the Point of Care ELISA test for Feline Leukemia Virus (FeLV) antigens and antibodies to feline immunodeficiency virus (FIV). Piroplasms compatible with Cytauxzoon spp. were observed in the smear, and the tests performed were positive for Cytauxzoon felis, Mycoplasma haemofelis, and FIV.
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André MR, Adania CH, Allegretti SM, Machado RZ. Hemoplasmas in wild canids and felids in Brazil. J Zoo Wildl Med. 2011;42(2):342-7. http://dx.doi.org/10.1638/2010-0198.1. PMid:22946419.
André MR, Adania CH, Machado RZ, Allegretti SM, Felippe PAN, Silva KF, Nakaghi ACH, Dagnone AS. Molecular detection of Cytauxzoon spp. in asymptomatic Brazilian wild captive felids. J Wildl Dis. 2009;45(1):234-7. http://dx.doi.org/10.7589/0090-3558-45.1.234. PMid:19204356.
André MR, Calchi AC, Furquim MEC, Andrade I, Arantes PVC, Lopes LCM, Demarchi IKLN, Figueiredo MAP, Lima CAP, Machado RZ. Molecular detection of tick-borne agents in cats from Southeastern and Northern Brazil. Pathogens. 2022;11(1):106. http://dx.doi.org/10.3390/pathogens11010106. PMid:35056054.
André MR, Filgueira KD, Calchi AC, Sousa KCM, Gonçalves LR, Medeiros VB, Ximenes PA, Lelis ICNG, Meireles MVN, Machado RZ. Co-infection with arthropod-borne pathogens in domestic cats. Rev Bras Parasitol Vet. 2017;26(4):525-31. http://dx.doi.org/10.1590/s1984-29612017064. PMid:29160357.
Aschenbroich SA, Rech RR, Sousa RS, Carmichael KP, Sakamoto K. Pathology in practice: Cytauxzoon felis infection. J Am Vet Med Assoc. 2012;240(2):159-61. http://dx.doi.org/10.2460/javma.240.2.159. PMid:22217023.
Beatty JA, Sykes JE. Feline immunodeficiency virus infection. In: Sykes JE, editor. Greene’s infectious diseases of the dog and cat. 5th ed. St. Louis: Saunders; 2021. p. 414-28. http://dx.doi.org/10.1016/B978-0-323-50934-3.00033-1.
Clarke LL, Rissi DR. Neuropathology of natural Cytauxzoon felis infection in domestic cats. Vet Pathol. 2015;52(6):1167-71. http://dx.doi.org/10.1177/0300985814564986. PMid:25572263.
Díaz-Regañón D, Villaescusa A, Ayllón T, Rodríguez-Franco F, García-Sancho M, Agulla B, Sainz Á. Epidemiological study of hemotropic Mycoplasmas (hemoplasmas) in cats from central Spain. Parasit Vectors. 2018;11(1):140. http://dx.doi.org/10.1186/s13071-018-2740-9. PMid:29554981.
Feldman BV, Zinkl JG, Jain NC, Schalm OW. Schalm’s veterinary hematology. 6th ed. New Jersey: Wiley-Blackwell; 2016.
Firmino FP, Aquino LC, Marçola TG, Bittencourt MV, McManus CM, Paludo GR. Frequency and hematological alterations of different hemoplasma infections with retrovirusis co-infections in domestic cats from Brazil. Pesq Vet Bras. 2016;36(8):731-6. http://dx.doi.org/10.1590/S0100-736X2016000800009.
Furtado MM, Taniwaki SA, Metzger B, Paduan KS, O’Dwyer HL, Jácomo ATA, Porfírio GEO, Silveira L, Sollmann R, Tôrres NM, Ferreira Neto JS. Is the free-ranging jaguar (Panthera onca) a reservoir for Cytauxzoon felis in Brazil? Ticks Tick Borne Dis. 2017;8(4):470-6. http://dx.doi.org/10.1016/j.ttbdis.2017.02.005. PMid:28196774.
Kaneko JJ, Harvey JW, Bruss ML. Clinical biochemistry of domestic animals. 6th ed. Burlington: Academic Press, 2008.
Little S, Levy J, Hartmann K, Hofmann-Lehmann R, Hosie M, Olah G, Denis KS. AAFP feline retrovirus testing and management guidelines. J Feline Med Surg. 2020;22(1):5-30. http://dx.doi.org/10.1177/1098612X19895940. PMid:31916872.
Maia LMP, Cerqueira AMF, Macieira DB, Souza AM, Moreira NS, Silva AV, Messick JB, Ferreira RF, Almosny NRP. Cytauxzoon felis and ‘Candidatus Mycoplasma haemominutum’ coinfection in a Brazilian domestic cat (Felis catus). Rev Bras Parasitol Vet. 2013;22(2):289-91. http://dx.doi.org/10.1590/S1984-29612013000200049. PMid:23856727.
Mendes-de-Almeida F, Labarthe N, Guerrero J, Faria MCF, Branco AS, Pereira CD, Barreira JD, Pereira MJS. Follow-up of the health conditions of an urban colony of free-roaming cats (Felis catus Linnaeus, 1758) in the city of Rio de Janeiro, Brazil. Vet Parasitol. 2007;147(1-2):9-15. http://dx.doi.org/10.1016/j.vetpar.2007.03.035. PMid:17481822.
Messick JB. Hemotrophic mycoplasmas (hemoplasmas): a review and new insights into pathogenic potential. Vet Clin Pathol. 2004;33(1):2-13. http://dx.doi.org/10.1111/j.1939-165X.2004.tb00342.x. PMid:15048620.
Moreira TA, Macedo Júnior GL, Souza RR, Bandarra MB, Szabó MPJ. Puma (Puma concolor) predating sheep in Uberlândia, Brazil: physical injuries, stress and myopathy. Biosci J. 2018;34(3):697-702. http://dx.doi.org/10.14393/BJ-v34n3a2018-37252.
Raimundo JM, Guimarães A, André MR, Baldani CD. Cytauxzoon felis DNA detection in healthy cats from Rio de Janeiro, Brazil. J Parasitol. 2021;107(5):676-8. http://dx.doi.org/10.1645/19-159. PMid:34473290.
Rizzi TE, Reichard MV, Cohn LA, Birkenheuer AJ, Taylor JD, Meinkoth JH. Prevalence of Cytauxzoon felis infection in healthy cats from enzootic areas in Arkansas, Missouri, and Oklahoma. Parasit Vectors. 2015;8(1):13. http://dx.doi.org/10.1186/s13071-014-0618-z. PMid:25566776.
Snider TA, Confer AW, Payton ME. Pulmonary histopathology of Cytauxzoon felis infections in the cat. Vet Pathol. 2010;47(4):698-702. http://dx.doi.org/10.1177/0300985810364527. PMid:20442419.
Sykes JE. Feline hemotropic mycoplasmas. J Vet Emerg Crit Care. 2010;20(1):62-9. http://dx.doi.org/10.1111/j.1476-4431.2009.00491.x. PMid:20230435.
Tarigo JL, Scholl EH, Bird DM, Brown CC, Cohn LA, Dean GA, Levy MG, Doolan DL, Trieu A, Nordone SK, Felgner PL, Vigil A, Birkenheuer AJ. A novel candidate vaccine for cytauxzoonosis inferred from comparative apicomplexan genomics. PLoS One. 2013;8(8):e71233. http://dx.doi.org/10.1371/journal.pone.0071233. PMid:23977000.
Tasker S. Haemotropic mycoplasmas: what’s their real significance in cats? J Feline Med Surg. 2010;12(5):369-81. http://dx.doi.org/10.1016/j.jfms.2010.03.011. PMid:20417898.
Willi B, Boretti FS, Baumgartner C, Tasker S, Wenger B, Cattori V, Meli ML, Reusch CE, Lutz H, Hofmann-Lehmann R. Prevalence, risk factor analysis, and follow-up of infections caused by three feline hemoplasma species in cats in Switzerland. J Clin Microbiol. 2006;44(3):961-9. http://dx.doi.org/10.1128/JCM.44.3.961-969.2006. PMid:16517884.
Woods JE, Brewer MM, Hawley JR, Wisnewski N, Lappin MR. Evaluation of experimental transmission of ‘Candidatus Mycoplasma haemominutum’ and Mycoplasma haemofelis by Ctenocephalides felis to cats. Am J Vet Res. 2005;66(6):1008-12. http://dx.doi.org/10.2460/ajvr.2005.66.1008. PMid:16008224.
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