Behavioral and biochemical effects of xylazine: possible interactions between central noradrenergic-dopaminergic systems

Authors

  • Helenice de Souza Spinosa Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Silvana Lima Górniak Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • João Palermo Neto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Maria Martha Bernardi

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.1993.52036

Keywords:

Xylazine, Behavior (animal), Stereotyping, Catatonia

Abstract

Behavioral and biochemical effects of xylazine were studied both in rats and mice. The results showed that xylazine: a) decreased the general activity of rats and mice observed in an open field; b) was unable to produce catatonia and suppressed haloperidol-induced catatonia in mice; c) increased apomorphine-induced stereotyped behavior in rats; and d) increased brain noradrenaline without effect on brain dopamine levels. These results were discussed in the light of a possible interference of xylazine with brain noradrenergic system and, thus, with the dynamic interaction between noradrenergic-dopaminergic neurons within the Central Nervous System.

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Published

1993-12-03

Issue

Vol. 30 (1993): Suplemento 1

Section

ANIMAL PATHOLOGY

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Spinosa H de S, Górniak SL, Palermo Neto J, Bernardi MM. Behavioral and biochemical effects of xylazine: possible interactions between central noradrenergic-dopaminergic systems. Braz. J. Vet. Res. Anim. Sci. [Internet]. 1993 Dec. 3 [cited 2025 Jan. 2];30(supl.):221-6. Available from: https://revistas.usp.br/bjvras/article/view/52036