Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study

Authors

  • Ji Xiong Third Military Medical University; Daping Hospital
  • Jun Wang Chinese People’s Armed Police Force
  • Juan Huang Third Military Medical University; Daping Hospital
  • Wenjing Sun Third Military Medical University; Daping Hospital
  • Jun Wang Third Military Medical University; Daping Hospital
  • Dongfeng Chen Third Military Medical University; Daping Hospital

DOI:

https://doi.org/10.6061/clinics/2015(08)06

Abstract

OBJECTIVE: Little is known about metabolic factors in cirrhotic patients in China. Therefore, we aimed to quantify the prevalence of both metabolic factors and non-alcoholic steatohepatitis-related liver cirrhosis in China. METHODS: The medical records of 1,582 patients diagnosed with liver cirrhosis from June 2003 to July 2013 at Daping Hospital (Chongqing, China) were retrospectively reviewed through a computer-generated search. RESULTS: Serum hepatitis B virus surface antigen was present in 1,083 (68.5%) patients, and hepatitis B was found to be the only etiological factor in 938 (59.3%) of all patients. Obesity, diabetes mellitus, and arterial hypertension were observed in 229 (14.5%), 159 (10.1%), and 129 (8.2%) patients, respectively. From 2012-2013, the proportion of non-alcoholic steatohepatitis-related liver cirrhosis increased to 3.2%, whereas the average proportion of non-alcoholic steatohepatitis-related liver cirrhosis in the previous ten years was 1.9%. The incidence of hepatocellular carcinoma was much higher in males than in females (6.3% vs. 3.7%, respectively, p=0.036). Obesity and diabetes mellitus did not significantly increase the incidence of hepatocellular carcinoma in the whole cirrhotic group. The presence of hepatitis B virus was the only risk factor for hepatocellular carcinoma in cirrhotic patients (p<0.001). CONCLUSIONS: Although hepatitis B virus remains the main etiology of liver cirrhosis in China, steatohepatitis-related liver cirrhosis is increasing in frequency. Hepatitis B virus was the sole significant risk factor for hepatocellular carcinoma in the whole cirrhotic group in the present study, in contrast to obesity and diabetes mellitus, for which only a trend of increased hepatocellular carcinoma was found.

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Published

2015-08-01

Issue

Section

Clinical Sciences

How to Cite

Xiong, J., Wang, J., Huang, J., Sun, W., Wang, J., & Chen, D. (2015). Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study . Clinics, 70(8), 563-568. https://doi.org/10.6061/clinics/2015(08)06