Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice

Authors

  • Valiollah Hajhashemi Isfahan University of Medical Sciences; School of Pharmacy and Pharmaceutical Sciences; Isfahan Pharmaceutical Sciences Research Center
  • Mohammad Rabbani Isfahan University of Medical Sciences; School of Pharmacy and Pharmaceutical Sciences; Department of Pharmacology
  • Alireza Ghanadi Isfahan University of Medical Sciences; School of Pharmacy and Pharmaceutical Sciences; Department of Pharmacognosy
  • Elahe Davari Isfahan University of Medical Sciences; School of Pharmacy and Pharmaceutical Sciences; Department of Pharmacology

DOI:

https://doi.org/10.1590/S1807-59322010001000020

Keywords:

Apiaceae, diazepam, elevated plus-maze, ketamine, spontaneous motor activity

Abstract

INTRODUCTION: We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae). METHODS: We used elevated plus maze, spontaneous motor activity and ketamine-induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n-decanal (70.1%) and alpha-pinene (12.4%) constituted the major components. RESULTS: In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25-200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine-induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect

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Published

2010-01-01

Issue

Vol. 65 No. 10 (2010)

Section

Basic Research

How to Cite

Hajhashemi, V., Rabbani, M., Ghanadi, A., & Davari, E. (2010). Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice . Clinics, 65(10), 1037-1042. https://doi.org/10.1590/S1807-59322010001000020