Association of sleep disorders and clinical characteristics of children with cystic fibrosis
DOI:
https://doi.org/10.1590/Keywords:
Pediatrics;, Sleep Disorders, Cystic FibrosisAbstract
This study aims to verify the relationship of
sleep disorders (SD) with clinical features in children with
cystic fibrosis. This analytical cross-sectional study was
carried out in individuals with cystic fibrosis, who were
divided according to their age: from two to 43 months
in the infants’ group (IG) and from five to 14 years in the
schoolchildren’s group (SG). Information on genotype,
disease severity, and presence of pathogens were collected
from medical records. To evaluate SD, the brief infant sleep
questionnaire was applied in the IG and the sleep disturbance
scale for children in the SG. Nutritional status categorized
the percentiles based on the body mass index. In the
SG, spirometry and pulse oscillometry were conducted.
The chi-squared test was used to analyze the association
between variables, and Spearman’s coefficient was applied
for quantitative variables (p<0.05). In total, 33 individuals
participated in this study, with a mean age of 1.49±1.15 years
in the IG and of 11.38±2.88 years in the SG. In the IG, 72.2%
were eutrophic and 22.2% were prone to SD. In the SG,
low weight occurred in 80% of its members and in 73.3%
in the SD (a mean of 42.27±7.75 in the sleep disturbance
scale for children). An association occurred between SD and nutritional status in the total sample, with SD predominating
in individuals with low weight (p=0.013). this study found a trend
toward SD in this population, especially in underweight children
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References
Santana NN, Chaves CRMM, Goncalves CP, Gomes Junior SCS.
Factors Associated to quality of life in children and adolescents
with cystic fibrosis. Rev Paul Pediatr. 2020;38:e2018397.
doi: 10.1590/1984-0462/2020/38/2018397.
Elborn JS. Cystic fibrosis. Lancet. 2016;388(10059):2519-31.
doi: 10.1016/s0140-6736(16)00576-6.
Shakkottai A, O’Brien LM, Nasr SZ, Chervin RD.
Sleep disturbances and their impact in pediatric cystic fibrosis.
Sleep Med Rev. 2018;42:100-10. doi: 10.1016/j.smrv.2018.07.002.
Cohen-Cymberknoh M, Atia O, Gileles-Hillel A, Kerem E, Reiter
J. Sleep disorders in patients with primary ciliary dyskinesia,
cystic fibrosis with and without pancreatic insufficiency. Respir
Med. 2019;151:96-101. doi: 10.1016/j.rmed.2019.03.022.
scar-Urrutia M, Madrid-Carbajal CJ, Rubinos-Cuadrado G,
Fernández-Álvarez R, Vásquez-López MJ, Hernández-González
C, et al. Objective and subjective sleep efficiency in adult
patients with cystic fibrosis and impact on quality of life. Lung.
;196(6):761-7. doi: 10.1007/s00408-018-0167-x.
Reiter J, Gileles-Hillel A, Cohen-Cymberknoh M, Rosen D,
Kerem E, et al. Sleep disorders in cystic fibrosis: a systematic
review and meta-analysis. Sleep Med Rev. 2020;51:101279.
doi: 10.1016/j.smrv.2020.101279
Lumertz MS, Pinto LA. Sleep-disordered breathing in cystic
fibrosis pediatric subjects. Sleep Sci. 2019;12(3):165-70.
doi: 10.5935/1984-0063.20190079
Kanga J, Kuhn R, Craigmyle L, Haverstock D, Church D.
Cystic fibrosis clinical score: A new scoring system to evaluate
acute pulmonary exacerbation. Clin Ther. 1999;21(8):1343-56.
doi: 10.1016/s0149-2918(99)80035-6.
Ramsey BW. Management of Pulmonary Disease in Patients with
Cystic Fibrosis. N Engl J Med. 1996;335(15):1167. doi: 10.1056/
nejm199610103351522.
Nunes ML, Kampff JPR, Sadeh A. BISQ Questionnaire for
Infant Sleep Assessment: translation into brazilian portuguese.
Sleep Sci. 2012;5(3):89-91.
Ferreira VR, Carvalho LBC, Ruotolo F, Morais JF, Prado
LB, Prado GF. Sleep disturbance scale for children:
translation, cultural adaptation, and validation. Sleep Med.
;10(4):457-63. doi: 10.1016/j.sleep.2008.03.018.
BVS. Biblioteca Virtual em Saúde. Atenção primária à saúde.
Programa Nacional Telessaúde Brasil Redes. Cálculo do Índice
de Massa Corporal (MC) [Internet]. 2009 [cited 2009 jul 7].
Disponível em: http://aps.bvs.br/apps/calculadoras/?page=7.
Beydon N, Davis SD, Lombardi E, Allen JL, Arets HGM,
Aurora P, et al. An Official American Thoracic Society/European
Respiratory Society Statement: pulmonary function testing in
preschool children. Am J Resp Crit Care Med. 2007;175(12):1304-
doi: 10.1164/rccm.200605-642st
Manual IOS- Jaeger Impulse Oscillometry. Measurement Program
IOS basic1e. cap. 15, p. 1-28. Versão 5.2.
Assumpcão MS, Goncalves RM, Martins R, Bobbio TG,
Schivinski CI. Reference equations for impulse oscillometry
system parameters in healthy brazilian children and adolescents.
Respir Care. 2016;61(8):1090-9. doi: 10.4187/respcare.04226.
Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ,
Cooper BG, Hall GL, et al. Standardization of Spirometry 2019
Update. An Official American Thoracic Society and European
Respiratory Society Technical Statement. Am J Respir Crit Care
Med. 2019;200(8):e70-88. doi: 10.1164/rccm.201908-1590ST.
Pereira CAC, Sato T, Rodrigues SC. Novos valores de referência
para espirometria forçada em brasileiros adultos de raça
branca. J Bras Pneumol. 2007;33(4):397-406. doi: 10.1590/
S1806-37132007000400008
Athanazio RA, Silva Filho LVRF, Vergara AA, Ribeiro AF, Riedi CA,
Procianoy ELFA, et al. Diretrizes brasileiras de diagnóstico
e tratamento da fibrose cística. J Bras Pneumol. 2017;43(3):219-
doi: 10.1590/s1806-37562017000000065.
Doershuk CF, Matthews LW, Tucker AS, Nudelman H, Eddy G,
Wise M, et al. A 5 year clinical evaluation of a therapeutic program
for patients with cystic fibrosis. J Pediatr. 1996;65(5):677-93.
doi: 10.1016/s0022-3476(64)80152-9.
Carneiro GV, Oliveira FS, Pereira LA, Rezende ÉRMA, Gonçalves
LCP, Azevedo VMGO. Association between phenotypic and
genotypic characteristics and disease severity in individuals
with cystic fibrosis. Rev Paul Pediatr. 2023;41:e2021286.
doi: 10.1590/1984-0462/2023/41/2021286.
Vanden Branden SL, McMullen A, Schechter MS, pasta DJ,
Michaelis RL, Konstan MW, et al. Lung function decline from
adolescence to young adulthood in cystic fibrosis. Pediatr
Pulmonol. 2012;47(2):135-43. doi: 10.1002/ppul.21526.
Calella P, Valerio G, Brodlie M, Donini LM, Siervo M. Cystic fibrosis,
body composition, and health outcomes: a systematic review.
Nutrition. 2018;55-56:131-9. doi: 10.1016/j.nut.2018.03.052.
Ararat E, Sonawalla A, Berlinski A, Tas E. Nutritional status
between 5-10 years is associated with cystic fibrosis-related
diabetes in adolescence. Pediatr Pulmonol. 2021;56(10):3217-
doi: 10.1002/ppul.25572.
Barbosa RRB, Liberato FMG, Freitas Coelho P, Vidal PR,
Carvalho RBCO, Donadios MVF. Sleep disordered breathing and
markers of morbidity in children and adolescents with cystic
fibrosis. Pediatr Pulmonol. 2020;55(8):1974-83. doi: 10.1002/
ppul.24780.
Sousa LP, Liberato FMG, Vendrusculo FM, Donadio MVF,
Barbosa RRB. Obstructive sleep apnea in children and
adolescents with cystic fibrosis and preserved lung function
or mild impairment: a systematic review and meta-analysis
of prevalence. Sleep Med. 2021;88:36-43. doi: 10.1016/j.
sleep.2021.09.017.
Moreau L, Crenesse D, Berthier F, Albertini M. Relationship
between impulse oscillometry and spirometric indices in
cystic fibrosis children. Acta Pediatric. 2020;98(6):1019-23.
doi: 10.1111/j.1651-2227.2009.01246.x.
Wamosy RMG, Assumpção MS, Parazzi PLF, Ribeiro JD, Roesler
H, Schvinski CIS. Reliability of impulse oscillometry parameters
in healthy children and in children with cystic fibrosis. Int J Clin
Pract.2020;75(4):e13715. doi: 10.1111/ijcp.13715.
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