Um Maternal transfer of anti-SARS-CoV-2 antibodies through immunization and breastfeeding for 12 months
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2024.213538Keywords:
COVID-19 vaccines, Immunity, Maternally-acquired, Breastfeeding, PregnancyAbstract
In February 2023, according to the World Health Organization, there had been more than 700 million cases of COVID-19 worldwide. Maternal immunization has become a hotspot in research
on the transplacental transfer of antibodies to the fetus. Vaccinations administered during pregnancy are intended to protect the mother from serious illness. Case presentation: In this report, we describe a case wherein the transfer of anti-SARS-CoV-2 antibodies to the fetus, baby, and infant was observed through immunization and breastfeeding. Maternal antibodies were detected in the umbilical cord at birth, in breast milk for up to 10 mo after birth, and in the child’s blood for up to 1 y of age, which suggests the importance of vaccination during pregnancy as well as maternal and neonatal protection. Conclusion: When an vaccine was administered to the pregnant patient, effective immunological results were obtained in terms of both placental transfer and breastfeeding, for up to 1 y of age.
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References
World Health Organization. WHO. World Health Organization Coronavirus Disease (COVID-19). 2023. Available online at: <https://covid19.who.int/>. (Accessed: February 21, 2023).
Zhu N, Zhang D, Wang W, Li X Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N. Engl J Med. 2020,382(8):727-733. doi: 10.1056/NEJMoa2001017.
Boehmer TK, DeVies J, Caruso E, van Santen KL, Tang S, Black CL, Hartnett KP, Kite-Powell A, Dietz S, Lozier MJ, et. al. Changing Age Distribution of the COVID-19 Pandemic. MMWR Morb Mortal Wkly Rep. 2020,69,1404-1409. doi:10.15585/mmwr.mm6939e1.
Schwartz DA, Graham AL; Potential Maternal and Infant Outcomes from (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections. Viruses. 2020,12(2):194. doi: 10.3390/v12020194.
Zambrano LD, Ellington S, Strid P, Galang RR, Oduyebo T, Tong VT, Woodworth KR, Nahabedian, JF, 3rd, Azziz-Baumgartner E, Gilboa SM, Meaney-Delman D. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status. 2020. MMWR Morb Mortal Wkly Rep. 2020,69(44):1641-1647.doi:10.15585/mmwr.mm6944e3.
Munoz FM, Posavad CM, Richardson BA, Badell ML, Bunge KE, Mulligan MJ, Parameswaran L, Kelly CW, Olson-Chen C, Novak RM, Brady RC, Pasetti MF, Defranco EA, Gerber JS, Mallory C. Shriver M, Suthar MS, Coler RN, Berube BJ, So Hee Kim M, Piper JM, Ashley M. Miller M, Cardemil CV, Neuzil KM, Beigi RH; DMID 21-0004 Study Group. COVID-19 booster vaccination during pregnancy enhances maternal binding and neutralizing antibody responses and transplacental antibody transfer to the newborn. Vaccine. 2023 Jun 13. doi: 10.1016/j.vaccine.2023.06.032.
Breslin N, Baptiste C, Gyamfi-Bannerman C, Miller R, Martinez R, Bernstein K, Ring L, Landau R, Purisch S, Friedman AM, et al. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM. 2020. (2):100118. doi: 10.1016/j.ajogmf.2020.100118.
Saji F, Samejima Y, Kamiura S, Koyama M. Dynamics of immunoglobulins at the feto-maternal interface. Rev Reprod. 1999 (2):81-9. doi: 10.1530/ror.0.0040081.
Brazil. National Immunization Program - Vaccination - Actions and Programs. 2021. Available online at: <https://www.gov.br/saude/pt-br/>. (Accessed Feb 21, 2023).
Brazil. Health from A to Z: National Vaccination Calendar. 2022. Available online at: <https://www.gov.br/saude/pt-br/>. (Accessed Feb 21, 2023).
Brazil. National Plan for the Operationalization of Vaccination against Covid-19 – PNO (2nd edition with ISBN). 2022. Available online at: <https://www.gov.br/saude/pt-br/>. (Accessed Feb 21, 2023).
Geoghegan S, Shuster S, Butler KM, Feemster KA. Understanding Barriers and Facilitators to Maternal Immunization: A Systematic Narrative Synthesis of the Published Literature. Matern Child Health J. 2022 (11):2198-2209. doi: 10.1007/s10995-022-03508-0.
Razzaghi H, Meghani M, Pingali C, Crane B, Naleway A, Weintraub E, Kenigsberg TA, Lamias MJ, Irving SA, Kauffman TL, et al. COVID-19 Vaccination Coverage Among Pregnant Women During Pregnancy - Eight Integrated Health Care Organizations, United States, December 14, 2020-Mai 8, 2021. MMWR Morb Mortal Wkly Rep. 2021. 70(24):895-899. doi: 10.15585/mmwr.mm7024e2.
Blakeway H, Prasad S, Kalafat, E, Heath PT, Ladhani SN, Le Doare K, Magee LA, O'Brien P, Rezvani A, von Dadelszen P et al. COVID-19 vaccination during pregnancy: coverage and safety. Am J Obstetrics Gynecol. 2022. 226(2): 236.e1–236.e14. doi: 10.1016/j.jog.2021.08.007.
Fell DB, Dhinsa T, Alton GD, Török E, Dimanlig-Cruz S, Regan AK, Sprague AE, Buchan SA, Kwong JC, Wilson SE, et al. Association of COVID-19 Vaccination in Pregnancy with Adverse Peripartum Outcomes. JAMA. 2022. 327(15):1478–1487. doi: 10.1001/population.2022.4255.
Halasa NB, Olson SM, Staat MA, Newhams MM, Price AM, Boom JA, Sahni LC, Cameron MA, Pannaraj PS, Bline KE, et al. Overcoming COVID-19 Investigators; Overcoming COVID-19 Network. Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19-Associated Hospitalization in Infants Aged <6 Months - 17 States, July 2021-January 2022. MMWR Morb Mortal Wkly Rep. 2022. 71(7):264-270. doi: 10.15585/mmwr.mm7107e3.
Beharier O, Plitman Mayo R, Raz T, Nahum Sacks K, Schreiber L, Suissa-Cohen Y, Chen R, Gomez-Tolub R, Hadar E, Gabbay-Benziv R. et.al. Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine. J Clin Invest. 2021. 131(13): e150319. doi: 10.1172/JCI150319.
CDC- Center for Disease Control and Prevention. New CDC data: COVID-19 Vaccination safe for pregnant people. Available online at: < https://www.cdc.gov/>. (Acessado em 21 fev 2023).
Mithal LB, Otero S, Shanes ED, Goldstein JA, Miller ES. Cord blood antibodies following maternal coronavirus disease 2019 vaccination during pregnancy. Am J Obstet Gynecol 2021. 225(2):192-194. doi: 10.1016/j.ajog.2021.03.035.
Gray KJ, Bordt EA, Atyeo C, Deriso E, Akinwunmi B, Young N, Baez AM, Shook LL, Cvr D, James K et.al. Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study. Am J Obstet Gynecol 2021. 225(3): 303.e1-303.e17. doi: 10.1016/j.ajog.2021.03.023.
Juncker HG, Mulleners SJ, van Gils MJ, de Groot CJM, Pajkrt D, Korosi A, van Goudoever JB, van Keulen BJ. The Levels of SARS-CoV-2 Specific Antibodies in Human Milk Following Vaccination. J Hum Lact. 2021. 37(3):477-484. doi: 10.1177/08903344211027112.
Prabhu M, Murphy EA, Sukhu AC, Yee J, Singh S, Eng D, Zhao Z, Riley LE, Yang YJ. Antibody Response to Coronavirus Disease 2019 (COVID-19) Messenger RNA Vaccination in Pregnant Women and Transplacental Passage Into Cord Blood. Obstet Gynecol. 2021. 1;138(2):278-280. doi: 10.1097/AOG.0000000000004438.
ACOG- American College for Obstetricians and Gynecologists. COVID-19 Vaccination considerations for obstetric-gynecologic care. Available online at: < https://www.acog.org/>. (Acesso em 21 fev 2023).
CDC. Centers for Disease Control and Prevention. COVID-19 Vaccines While Pregnant or Breastfeeding. 2022. Disponível online em: <https://www.cdc.gov/>. (Acessado em 22 fev. 2023).
Menegali BT, Schuelter-Trevisol F, Barbosa AN, Izidoro TM, Feurschuette OHM, Marcon CEM, Trevisol DJ. Vertical transmission of maternal COVID-19 antibodies after CoronaVac vaccine: A case report. Rev Soc Bras Med Trop. 2021. 12;54:e0385. doi: 10.1590/0037-8682-0385-2021.
Palacios R, Patiño EG, de Oliveira Piorelli R, Conde MTRP, Batista AP, Zeng G, Xin Q, Kallas EG, Flores J, Ockenhouse CF et al. Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac - PROFISCOV: A structured summary of a study protocol for a randomised controlled trial. Trials. 2020. 21(1):853. doi: 10.1186/s13063-020-04775-4.
Eick AA, Uyeki TM, Klimov A, Hall H, Reid R, Santosham M, O'Brien, KL. Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med. 2011. 165(2):104-11. doi: 10.1001/archpediatrics.2010.192.
Shook LL, Atyeo CG, Yonker LM, Fasano A, Gray KJ, Alter G, Edlow AG. Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection. JAMA. 2022. 327(11):1087-1089. doi: 10.1001/jama.2022.1206.
Perl SH, Uzan-Yulzari A, Klainer H, Asiskovich L, Youngster M, Rinott E, Youngster I. SARS-CoV-2-Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women. JAMA. 2021. 325(19):2013–2014. doi: 10.1001/population.2021.5782.
Young BE, Seppo AE, Diaz N, Rosen-Carole C, Nowak-Wegrzyn A, Cruz Vasquez JM, Ferri-Huerta R, Nguyen-Contant P, Fitzgerald T, Sangster MY, et al. Association of Human Milk Antibody Induction, Persistence, and Neutralizing Capacity With SARS-CoV-2 Infection vs mRNA Vaccination. JAMA Pediatr. 2022. 176(2):159-168. doi: 10.1001/jamapediatrics.2021.489
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Copyright (c) 2024 Carolina Rangel de Lima Santos, Kamily Fagundes Pussi, Iara Beatriz Andrade de Sousa, Manoel Sebastião da Costa Lima Junior, Herintha Coeto Neitzke-Abreu
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