Controle epigenético das drogas de abuso: novo aporte à saúde mental?
DOI:
https://doi.org/10.11606/issn.1806-6976.smad.2024.216898Palavras-chave:
Vulnerabilidade em Saúde, Transtornos Relacionados ao Uso de Substâncias, Saúde mental, EpigenômicaResumo
Objetivo: mapear a produção de conhecimento sobre o papel da epigenética na resposta às
drogas de abuso, bem como as alterações epigenéticas observadas na dependência e na saúde
mental. Metodologia: foi realizada uma revisão de escopo. A busca foi realizada nas bases
de dados bibliográficas: PubMed/Medline, Science Direct, Scopus, Bentham Science, Embase,
Web of Science e Gale Academic OneFile. Os dados gerados foram analisados tematicamente em
três etapas: a) seleção e análise dos artigos; b) análise de dados textuais; c) geração de mapas
bibliográficos. Resultados: a busca identificou 21 artigos relacionados aos efeitos epigenéticos
das drogas de abuso sobre os mecanismos geradores da dependência química. Conclusão:
os resultados obtidos permitiram identificar e verificar que mecanismos epigenéticos ocorrem em
resposta ao uso de drogas de abuso, resultando em alterações na expressão genética. Aponta-se
que a epigenética visa oferecer um mecanismo adicional de controle sobre a transcrição e a forma
como os genes são expressos, buscando mitigar o impacto das drogas de abuso no tratamento
de transtornos mentais e dependência química.
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