Control epigenético de las drogas de abuso: ¿nueva contribución a la salud mental?
DOI:
https://doi.org/10.11606/issn.1806-6976.smad.2024.216898Palabras clave:
Vulnerabilidad en Salud, Trastornos Relacionados con Sustancias, Salud Mental, EpigenómicaResumen
Objetivo: mapear la producción de conocimiento sobre el papel de la epigenética en respuesta
a las drogas de abuso, así como los cambios epigenéticos observados en la adicción y la salud
mental. Metodología: se realizó una revisión del alcance. La búsqueda se realizó en las bases
de datos bibliográficas: PubMed/Medline, Science Direct, Scopus, Bentham Science, Embase,
Web of Science y Gale Academic OneFile. Los datos generados fueron analizados temáticamente
en tres etapas: a) selección y análisis de artículos; b) análisis de datos textuales; c) generación de
mapas bibliográficos. Resultados: la búsqueda identificó 21 artículos relacionados con los efectos
epigenéticos de las drogas de abuso sobre los mecanismos que generan dependencia química.
Conclusión: los resultados obtenidos permitieron identificar y verificar que los mecanismos
epigenéticos ocurren en respuesta al uso de drogas de abuso, resultando así en cambios en la
expresión genética. Se señala que la epigenética pretende ofrecer un mecanismo adicional de
control sobre la transcripción y cómo se expresan los genes, buscando mitigar el impacto de las
drogas de abuso en el tratamiento de los trastornos mentales y la dependencia química.
Descargas
Referencias
Medina-Mora ME, Real T, Villatoro J, Natera G. Las drogas y la salud pública: ¿hacia dónde vamos? Salud Pública Méx [Internet]. 2013 [cited 2023 Oct 08];55(1):67-73. Available from: https://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S0036-36342013000100010
Scoppetta O, Castaño Pérez G. El enfoque de salud pública en la política de drogas en Colombia. Health Addict . 2018;18(1):81-8. https://doi.org/10.21134/haaj.v18i1.349
Russell C, Law J, Bonn M, Rehm J, Ali F. The increase in benzodiazepine-laced drugs and related risks in Canada: The urgent need for effective and sustainable solutions. Int J Drug Policy. 2023;111:103933. https://doi.org/10.1016/j.drugpo.2022.103933
Koob G, Kreek MJ. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry. 2007;164:1149-59. https://doi.org/10.1176/appi.ajp.2007.05030503
Wise R, Koob G. The development and maintenance of drug addiction. Neuropsychopharmacology. 2014;39:254-62. https://doi.org/10.1038/npp.2013.261
Kreek MJ, Nielsen DA, Butelman ER, LaForge KS. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci. 2005;8:1450-7. https://doi.org/10.1038/nn1583
Kendler KS, Prescott CA, Myers J, Neale MC. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry. 2003;60(9):929-37. https://doi.org/10.1001/archpsyc.60.9.929
Kendler KS, Schmitt E, Aggen SH, Prescott CA. Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. Arch Gen Psychiatry. 2008;65(6):674-82. https://doi.org/10.1001/archpsyc.65.6.674
Agrawal A, Neale MC, Prescott CA, Kendler, KS. Cannabis and other illicit drugs: Comorbid use and abuse/dependence in males and females. Behav Genet. 2004;34:217-28. https://doi.org/10.1023/B:BEGE.0000017868.07829.45
Ajonijebu DC, Abboussi O, Russell VA, Mabandla MV, Daniels WMU. Epigenetics: a link between addiction and social environment. Cell Mol Life Sci. 2017 Aug;74(15):2735-47. https://doi.org/10.1007/s00018-017-2493-1
Mason B, Donaldson ST, Hunter RG. The developmental neuroepigenetics of substance abuse. J Drug Alcohol Res. 2018;7:1-27. https://doi.org/10.4303/jdar/236039
Cadet JL, Jayanthi S. Epigenetics of addiction. Neurochem Int. 2021;147:105069. https://doi.org/10.1016/j.neuint.2021.105069
Salmanzadeh H, Ahmadi-Soleimani SM, Azadi M, Halliwell RF, Azizi H. Adolescent substance abuse, transgenerational consequences and epigenetics. Curr Neuropharmacol. 2021;19(9):1560-9. https://doi.org/10.2174/1570159X19666210303121519
Werner CT, Altshuler RD, Shaham Y, Li X. Epigenetic mechanisms in drug relapse. Biol Psychiatry. 2021;89(4):331-8. https://doi.org/10.1016/j.biopsych.2020.08.005
Berruecos VL. Drogadicción, farmacodependencia y drogodependencia: definiciones, confusiones y aclaraciones. Cuicuilco [Internet]. 2010 [cited 2023 Oct 20];17(49):61-81. Available from: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0185-16592010000200005&lng=es&tlng=es
McLellan AT. Substance misuse and substance use disorders: Why do they matter in healthcare? Trans Am Clin Climatol Assoc [Internet]. 2017 [cited 2023 Oct 20];128(2017):112-30. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525418/?report=reader
Ferreira AP, Nichele CST, Wermuth MAD, Wermelinger ED. Uso y abuso de substancias en adultos mayores atendidos en Servicios de Salud Mental. Mem Inst Investig Cienc Salud. 2022;20:73-84. https://doi.org/10.18004/mem.iics/1812-9528/2022.020.01.73
Han DD, Gu HH. Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC Pharmacol. 2006;6:6. https://doi.org/10.1186/1471-2210-6-6
Yokoyama JS, Bonham LW, Sturm VE, Adhimoolam B, Karydas A, Coppola G, et al. The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia. Neuroimage Clin. 2015;9:283-90. https://doi.org/10.1016/j.nicl.2015.07.017
Brody GH, Beach SR, Philibert RA, Chen YF, Murry VM. Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design. Child Dev. 2009;80(3):645-61. https://doi.org/10.1111/j.1467-8624.2009.01288.x
Winham SJ, Biernacka JM. Gene-environment interactions in genome-wide association studies: current approaches and new directions. J Child Psychol Psychiatry. 2013;54(10):1120-34. https://doi.org/10.1111/jcpp.12114
Hamilton PJ, Nestler EJ. Epigenetics and addiction. Curr Opin Neurobiol. 2019;59:128-36. https://doi.org/10.1016/j.conb.2019.05.005
Lee JS, Jaini PA, Papa F. An Epigenetic Perspective on Lifestyle Medicine for Depression: Implications for Primary Care Practice. Am J Lifestyle Med. 2020;16(1):76-88. https://doi.org/10.1177/1559827620954779
Muller HR, Prado KB. Epigenética: um novo campo da genética. RUBS [Internet]. 2008 [cited 2023 Oct 20];1(3):61-9. Available from: http://www.colegiogregormendel.com.br/gm_colegio/pdf/2012/textos/3ano/biologia/8.pdf
Bali P, Im HI, Kenny P. Methylation, memory and addiction. Epigenetics. 2011;6(6):671-4. https://doi.org/10.4161/epi.6.6.15905
Ferreira AP, Nichele CST, Santos JB, Cruz-Hernández MJ. The complex epigenetic interaction in the predisposition to drug dependence: a systematic literature review. Res Soc Develop. 2022;11(7):e51911730216. https://doi.org/10.33448/rsd-v11i7.30216
Bierut LJ. Genetic vulnerability and susceptibility to substance dependence. Neuron. 2011;69(4):618-27. https://doi.org/10.1016/j.neuron.2011.02.015
Heinbockel T, Csoka AB. Epigenetic effects of drugs of abuse. Int J Environ Res Public Health. 2018;15(10):2098. https://doi.org/10.3390/ijerph15102098
Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil H. Chapter 11: Scoping Reviews (2020 version). In: Aromataris E, Munn Z, editors. JBI Manual for Evidence Synthesis. Adelaide: JBI; 2020. https://doi.org/10.46658/JBIMES-20-12
Peters MD, Godfrey CM, Khalil H, McInerney P, Parker D, Soares CB. Guidance for conducting systematic scoping reviews. Int J Evid Based Healthc. 2015;13(3):141-6. https://doi.org/10.1097/XEB.0000000000000050
Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169(7):467-73. https://doi.org/10.7326/M18-0850
Armstrong R, Hall BJ, Doyle J, Waters E. Scoping the scope’ of a Cochrane review. Publ Health. 2011;33(1):147-50. https://doi.org/10.1093/pubmed/fdr015
Santos CMC, Pimenta CAM, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev. Latino-Am. Enfermagem. 2007;15(3):508-11. https://doi.org/10.1590/S0104-11692007000300023
Ratinaud P. Iramuteq: Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires [Software]. 2009 [cited 2023 Oct 20]. Available from: http://www.iramuteq.org
Camargo BV, Justo AM. Iramuteq: um software gratuito para análise de dados textuais. Temas Psicol. 2013;21(2):513-8. https://doi.org/10.9788/TP2013.2-16
Lahlou S. L'analyse lexicale. Variances [Internet]. 1994 [cited 2023 Oct 20];3:13-24. Available from: https://www.researchgate.net/publication/220042506_L'analyse_lexicale/link/0deec51ae6089f02f1000000/download
Lahlou S. Text mining methods: an answer to Chartier and Meunier. Papers Soc Represent [Internet]. 2011 cited 2023 Oct 20];20(2):38-1. Available from: https://eprints.lse.ac.uk/46728/1/Text%20mining%20methods(lsero).pdf
van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84:523-38. https://doi.org/10.1007/s11192-009-0146-3
O’Brien BC, Harris IB, Beckman TJ, Reed DA, Cook DA. Standards for reporting qualitative research: a synthesis of recommendations. Acad Med. 2014;89(9):1245-51. https://doi.org/10.1097/ACM.0000000000000388
Nestler E. Transcriptional mechanisms of addiction: role of Delta FosB. Philos Trans R Soc Lond B Biol Sci. 2008;363(1507):3245-55. https://doi.org/10.1098/rstb.2008.0067
Deng JV, Rodriguiz RM, Hutchinson AN, Kim IH, Wetsel WC, West AE. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nat Neurosc. 2010;13(9):1128-36. https://doi.org/10.1038/nn.2614
Koob G, Volkow N. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35(1):217-38. https://doi.org/10.1038/npp.2009
Wong C, Mill J, Fernandes C. Drugs and addiction: an introduction to epigenetics. Addiction. 2011;106(3):480-9. https://doi.org/10.1111/j.1360-0443.2010.03321.x
Volkow N, Wang GJ, Fowler J, Tomasi D. Addiction circuitry in the human brain. Annu Rev Pharmacol Toxicol. 2012;52:321-36. https://doi.org/10.1146/annurev-pharmtox-010611-134625
Boyadjieva N, Varadinova M. Epigenetics of psychoactive drugs. J Pharm Pharmacol. 2012;64(10):1349-58. https://doi.org/10.1146/10.1111/j.2042-7158.2012.01475.x
Tuesta LM, Zhang Y. Mechanisms of epigenetic memory and addiction. EMBO J. 2014;33(10):1091-103. https://doi.org/10.1002/embj.201488106
Umesh S, Khess CRJ, Simlai J, Bose S. The role of epigenetic mechanisms in substance use disorders: An overview. Hereditary Genet. 2015;4,149. https://doi.org/10.4172/2161-1041.1000149
Farris SP, Harris RA, Ponomarev I. Epigenetic modulation of brain gene networks for cocaine and alcohol abuse. Front Neurosci. 2015;9,138124. https://doi.org/10.3389/fnins.2015.00176
McCowan TJ, Dhasarathy A, Carvelli L. The epigenetic mechanisms of amphetamine. Addict Prevention. 2015;Suppl 1:10. https://doi.org/10.13188/2330-2178.S100001
Szutorisz H, Hurd YL. Epigenetic effects of cannabis exposure. Biol Psych. 2016;79(7):586-94. https://doi.org/10.1016/j.biopsych.2015.09.014
Gajewski P, Turecki G, Robison A. Differential expression of FosB proteins and potential target genes in select brain regions of addiction and depression patients. PLoS One. 2016;11(8):e0160355. https://doi.org/10.1371/journal.pone.0160355
Walker D, Nestler E. Neuroepigenetics and addiction. Handb Clin Neurol. 2018;148:747-65. https://doi.org/10.1016/B978-0-444-64076-5.00048-X
Stewart AF, Fulton SL, Maze I. Epigenetics of drug addiction. Cold Spring Harb Perspect. 2021;11(7):a040253. https://doi.org/10.1101/cshperspect.a040253
Mazzeo F, Meccariello R. Cannabis and Paternal Epigenetic Inheritance. Int J Environ Res Publ Health. 2023;20(9):5663. https://doi.org/10.3390/ijerph20095663
Léveillé N, Melo CA, Agami R. Enhancer-associated RNAs as therapeutic targets. Expert Opin Biol Ther. 2015;15(5):723-34. https://doi.org/10.1517/14712598.2015.1029452
Zaret KS, Carroll JS. Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 2011;25(21):2227-41. https://doi.org/10.1101/gad.176826.111
Berger MF, Bulyk ML. Universal protein-binding microarrays for the comprehensive characterization of the DNA-binding specificities of transcription factors. Nat Protoc. 2009;4(3):393-411. https://doi.org/10.1038/nprot.2008.195
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2024 SMAD, Revista Eletrônica Saúde Mental Álcool e Drogas (Edição em Português)
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
