Fetal alcohol exposure through biomarker ethyl esters of fatty acids in meconium
DOI:
https://doi.org/10.11606/issn.1806-6976.smad.2023.190096Keywords:
Alcohol-Related Disorders, Pregnancy, MeconiumAbstract
Objective: to identify the evidence in the literature on methods that quantify the biomarkers of
fetal alcohol exposure present in the biological meconium matrix: fatty acid ethyl esters (FAEEs).
Methodology: search carried out in three databases, using the fixed expressions “fatty acid
ethylester AND meconium”. Articles published until July 2018 were selected, whose participants
were pregnant women who did or did not use alcohol and who had meconium samples collected
from their newborns. Results: among the 201 references found, 27 articles met the inclusion
criteria, extracting data from the selected articles, such as: test method (analysis), extraction
method, analyzed biomarkers, cut-off point, internal standard and amount of meconium used.
Conclusion: within the variability of the biomarkers FAEEs, Ethyl Linoleate, Ethyl Palmitate, Ethyl
Stearate and Ethyl Oleate, were more prevalent and in higher concentrations. The sum of FAEEs
is more adequate and reliable than the individual analysis.
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